化疗引起的周围神经病的治疗和诊断：最新进展。
Treatment and diagnosis of chemotherapy-induced peripheral neuropathy: An update.
机构信息
LSU Health Shreveport, Shreveport, LA, USA.
Department of Pharmaceutical Sciences, Regis University School of Pharmacy, Denver, CO 80221, USA.
出版信息
Biomed Pharmacother. 2022 Mar;147:112671. doi: 10.1016/j.biopha.2022.112671. Epub 2022 Jan 29.
Abstract
When peripheral neuropathy occurs due to chemotherapy treatment, it is referred to as chemotherapy-induced peripheral neuropathy (CIPN). Typically, symptoms are sensory rather than motor and include reduced feeling and heightened sensitivity to pressure, pain, temperature, and touch. The pathophysiology of CIPN is very complex, and it involves multiple mechanisms leading to its development which will be described specifically for each chemotherapeutic class. There are currently no approved or effective agents for CIPN prevention, and Duloxetine is the only medication that is an effective treatment against CIPN. There is an unavoidable necessity to develop preventative and treatment approaches for CIPN due to its detrimental impact on patients' lives. The purpose of this review is to examine CIPN, innovative pharmacological and nonpharmacological therapy and preventive strategies for this illness, and future perspectives for this condition and its therapies.
摘要
当外周神经病变是由化疗引起时，这种情况被称为化疗诱导的周围神经病（CIPN）。通常，症状是感觉性的而不是运动性的，包括感觉减退和对压力、疼痛、温度和触觉的敏感性增加。CIPN 的病理生理学非常复杂，它涉及多个导致其发展的机制，将针对每个化疗药物类别进行具体描述。目前，尚无针对 CIPN 的预防或有效药物，度洛西汀是唯一一种对 CIPN 有效的治疗药物。由于 CIPN 对患者生活造成严重影响，因此不可避免地需要开发预防和治疗 CIPN 的方法。本综述的目的是探讨 CIPN、创新性的药理学和非药理学治疗方法以及预防策略，以及对这种疾病及其治疗方法的未来展望。
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