Chu Patrick H W, Chan Henry H L, Brown Brian
Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2626-33. doi: 10.1167/iovs.06-0962.
To use the global flash multifocal electroretinogram (mfERG) in patients with asymmetric glaucoma to determine whether retinal function is affected in fellow eyes that have no glaucomatous visual field defects.
Forty normal subjects and 12 patients with asymmetric glaucoma were recruited for visual field and mfERG measurement. The mfERG was assessed by using a global-flash stimulation paradigm with four video frames: 103 scaled hexagonal elements followed by a dark frame, a global-flash frame, and a dark frame. The localized luminance difference was set at 96%, 65%, 49%, and 29% display contrast during the four different test conditions, respectively. The first-order kernel response was measured, and the "adaptive index" which has been used previously was calculated.
In fellow eyes with normal visual fields, the amplitude of the induced component (IC) was significantly reduced, and the adaptive index was reduced by a factor of almost 10 (P < 0.0001), as it was in the glaucomatous eyes. Although the adaptive index in the better (fellow) eye of the patients with glaucoma was slightly higher than in the eyes with diagnosed glaucoma, these differences were not statistically significant.
The significant reduction of the adaptive index in the better eyes in subjects with asymmetric glaucoma shows that the fast adaptive mechanism(s) were reduced in these eyes. This implies that eyes that have functionally normal visual acuity and visual fields have abnormal fast-adaptive mechanisms.
在非对称性青光眼患者中使用全视野闪光多焦视网膜电图（mfERG），以确定在没有青光眼性视野缺损的对侧眼中视网膜功能是否受到影响。
招募40名正常受试者和12名非对称性青光眼患者进行视野和mfERG测量。mfERG通过使用具有四个视频帧的全视野闪光刺激范式进行评估：103个缩放的六边形元素，随后是一个暗帧、一个全视野闪光帧和一个暗帧。在四种不同测试条件下，局部亮度差异分别设置为96%、65%、49%和29%的显示对比度。测量一阶核反应，并计算先前使用过的“适应性指数”。
在视野正常的对侧眼中，诱发成分（IC）的振幅显著降低，适应性指数降低了近10倍（P < 0.0001），与青光眼眼中的情况相同。尽管青光眼患者较好（对侧）眼的适应性指数略高于已确诊青光眼的眼睛，但这些差异无统计学意义。
非对称性青光眼患者较好眼中适应性指数的显著降低表明这些眼中的快速适应性机制降低。这意味着视力和视野功能正常的眼睛具有异常的快速适应性机制。
