Sarishvili A G, Nikuradze n A, Gurtskaia T E, Devdariani M I, Tsintsadze T G
Georgian Med News. 2007 Apr(145):73-6.
The linear interrelation between Systemic Arterial Blood Pressure and local Cerebral Blood Flow has been shown in experiments on rats with induced experimental hepatic encephalopathy. This is evidence of complete malfunctioning of the mechanism of Cerebral Blood Flow Autoregulation. Quantitative comparison of local Cerebral Blood Flow intensity in control and experimental (Hepatic Encephalopathy) animals has shown significant increase of the basic level of cerebral blood flow in rats with induced Hepatic Encephalopathy (p<0,05). On the basis of own and literature data the chain of developments in experimental hepatic encephalopathy was drawn: excess of Nitric Oxide because of hepatic failure can cause the cerebral vasodilatation with inadequate increase of cerebral blood flow intensity, resulting in malfunction of the cerebral blood flow autoregulation, increase of Blood Brain Barrier permeability, and penetration of toxic substances in nervous tissue. As a result of these--cognitive deficiency is developed (at the best) and hepatic coma (at the worst).
在诱导实验性肝性脑病的大鼠实验中，已表明体循环动脉血压与局部脑血流量之间存在线性相互关系。这证明了脑血流自动调节机制完全失灵。对照动物和实验（肝性脑病）动物局部脑血流强度的定量比较显示，诱导肝性脑病的大鼠脑血流基础水平显著增加（p<0.05）。根据自身及文献数据，得出实验性肝性脑病的发展过程：肝功能衰竭导致一氧化氮过量，可引起脑血管扩张，脑血流强度增加不足，进而导致脑血流自动调节功能障碍、血脑屏障通透性增加以及有毒物质渗透到神经组织中。这些情况的结果是（最好的情况）出现认知缺陷，（最坏的情况）则是肝昏迷。
