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一名肾移植受者髌骨的痛风性假肿瘤

Pseudotumor of gout in the patella of a kidney transplant recipient.

作者信息

Staub-Zähner Tanja, Garzoni Daniela, Fretz Christian, Lampert Christoph, Ohlschlegel Christian, Wüthrich Rudolf P, Fehr Thomas

机构信息

Kantonsspital, St Gallen, Switzerland.

出版信息

Nat Clin Pract Nephrol. 2007 Jun;3(6):345-9. doi: 10.1038/ncpneph0494.

Abstract

BACKGROUND

A 33-year-old renal transplant recipient presented with painless swelling of the right knee. Physical examination revealed an impressive knee joint effusion with no signs of inflammation. The patient did not remember a recent trauma, but he mentioned a strain 3 years earlier; radiographic findings had been normal at that time. The patient had suffered from end-stage renal disease due to chronic glomerulonephritis and had previously undergone two transplantations. At presentation, his kidney function was stable under treatment with ciclosporin, azathioprine and steroids.

INVESTIGATIONS

Conventional radiography revealed a tumor at the superolateral pole of the right patella. Extensive soft tissue invasion and bone destruction was seen on MRI. A knee arthroscopy with biopsy, performed to aid diagnosis, showed extensive chondrocalcinosis macroscopically; histologically, gouty tophi were found.

DIAGNOSIS

Pseudotumor of gout in the patella.

MANAGEMENT

Uric-acid-lowering therapy with benzbromarone was started immediately after diagnosis. A local arthroscopic debridement of the right knee joint was performed 4 months later, and the patient remained asymptomatic for the next 3 years.

摘要

背景

一名33岁的肾移植受者出现右膝无痛性肿胀。体格检查发现膝关节有明显积液,无炎症迹象。患者不记得近期有过外伤,但提到3年前有过拉伤;当时的影像学检查结果正常。该患者因慢性肾小球肾炎患有终末期肾病,此前已接受过两次移植手术。就诊时,他在环孢素、硫唑嘌呤和类固醇治疗下肾功能稳定。

检查

传统X线检查显示右髌骨上极有一个肿瘤。MRI显示有广泛的软组织侵犯和骨质破坏。为辅助诊断进行的膝关节镜检查及活检显示,肉眼可见广泛的软骨钙质沉着;组织学检查发现痛风石。

诊断

髌骨痛风性假肿瘤。

治疗

诊断后立即开始使用苯溴马隆进行降尿酸治疗。4个月后对右膝关节进行了局部关节镜清创术,患者在接下来的3年里一直无症状。

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