Morty Rory E, Eickelberg Oliver, Seeger Werner
Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Klinikstrasse 36, 35392, Giessen, Germany.
Intensive Care Med. 2007 Jul;33(7):1229-1240. doi: 10.1007/s00134-007-0662-7. Epub 2007 May 25.
Acute lung injury and the acute respiratory distress syndrome continue to be significant causes of morbidity and mortality in the intensive care setting. The failure of patients to resolve the alveolar edema associated with these conditions is a major contributing factor to mortality; hence there is continued interest to understand the mechanisms of alveolar edema fluid clearance.
The accompanying review by Vadász et al. details our current understanding of the signaling mechanisms and cellular processes that facilitate clearance of edema fluid from the alveolar compartment, and how these signaling processes may be exploited in the development of novel therapeutic strategies. To complement that report this review focuses on how intact organ and animal models and clinical studies have facilitated our understanding of alveolar edema fluid clearance in acute lung injury and acute respiratory distress syndrome. Furthermore, it considers how what we have learned from these animal and organ models and clinical studies has suggested novel therapeutic avenues to pursue.
在重症监护环境中，急性肺损伤和急性呼吸窘迫综合征仍然是导致发病和死亡的重要原因。患者无法消除与这些病症相关的肺泡水肿是导致死亡的主要因素；因此，人们持续关注了解肺泡水肿液清除的机制。
Vadász等人的随附综述详细阐述了我们目前对促进肺泡腔水肿液清除的信号传导机制和细胞过程的理解，以及这些信号传导过程如何在新型治疗策略的开发中得到应用。为补充该报告，本综述重点关注完整器官和动物模型以及临床研究如何促进我们对急性肺损伤和急性呼吸窘迫综合征中肺泡水肿液清除的理解。此外，它还考虑了我们从这些动物和器官模型以及临床研究中学到的知识如何提示了新的治疗途径以供探索。
