Taenaka Hiroki, Matthay Michael A
Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California, USA.
Department of Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, California, USA.
Anat Rec (Hoboken). 2025 Apr;308(4):1026-1039. doi: 10.1002/ar.25166. Epub 2023 Jan 23.
Impaired alveolar fluid clearance (AFC) is an important cause of alveolar edema fluid accumulation in patients with acute respiratory distress syndrome (ARDS). Alveolar edema leads to insufficient gas exchange and worse clinical outcomes. Thus, it is important to understand the pathophysiology of impaired AFC in order to develop new therapies for ARDS. Over the last few decades, multiple experimental studies have been done to understand the molecular, cellular, and physiological mechanisms that regulate AFC in the normal and the injured lung. This review provides a review of AFC in the normal lung, focuses on the mechanisms of impaired AFC, and then outlines the regulation of AFC. Finally, we summarize ongoing challenges and possible future research that may offer promising therapies for ARDS.
肺泡液体清除（AFC）受损是急性呼吸窘迫综合征（ARDS）患者肺泡水肿液积聚的重要原因。肺泡水肿导致气体交换不足和更差的临床结局。因此，了解AFC受损的病理生理学对于开发ARDS的新疗法很重要。在过去几十年中，已经进行了多项实验研究，以了解调节正常和受损肺中AFC的分子、细胞和生理机制。本综述回顾了正常肺中的AFC，重点关注AFC受损的机制，然后概述了AFC的调节。最后，我们总结了当前面临的挑战以及未来可能提供有前景的ARDS治疗方法的研究方向。
