Verhulst S L, Vekemans K, Ho E, Aerts L, Jacobs S, De Backer L A, Dhanapala H, Perera P, De Backer W A, Desager K N
Department of Pediatrics, University of Antwerp, Belgium.
Pediatr Pulmonol. 2007 Jul;42(7):579-83. doi: 10.1002/ppul.20599.
To investigate the association between wheezing and impaired sleep in Sri Lankan children, aged 6-12 years; and, to report the prevalence of asthma-related symptoms in these subjects.
The International Study of Asthma and Allergies in Childhood questionnaire and a separate sleep questionnaire were completed.
Of 800 originally distributed questionnaires, 652 were analyzed. Wheezing was present in 89 children (14%). Within this group, 66% reported wheezing in the last 12 months. Wheezing children had a significantly higher presence of snoring, restless sleep, nocturnal awakenings and daytime tiredness. Wheezing was found to be independently associated with restless sleep (odds ratio (OR) = 2.4). There was no association between wheezing and difficulties falling asleep, nocturnal awakenings, apneas, and daytime sleepiness and tiredness. After adjusting for possible confounders, the following significant associations were present: snoring and apneas (OR = 1.6), chronic rhinitis and apneas (OR = 1.6), snoring and restless sleep (OR = 3.2), chronic rhinitis and restless sleep (OR = 2.1), and hayfever and daytime tiredness (OR = 4.3). Wheezing was related to an increased risk of snoring (OR = 2.8) and subjects with chronic rhinitis had also an increased risk of snoring (OR = 1.7), adjusting for possible confounders.
The sleep of wheezing children was impaired compared with their non-wheezing peers, resulting in an increased prevalence of daytime tiredness. Upper airway symptoms, such as chronic rhinitis or hayfever, should be carefully considered in these children, as they might be responsible for these sleep problems.
调查6至12岁斯里兰卡儿童喘息与睡眠障碍之间的关联；并报告这些受试者中哮喘相关症状的患病率。
完成了儿童哮喘和过敏国际研究问卷以及一份单独的睡眠问卷。
在最初分发的800份问卷中，分析了652份。89名儿童（14%）有喘息症状。在这一组中，66%的儿童报告在过去12个月内有喘息。喘息儿童打鼾、睡眠不安、夜间觉醒和白天疲倦的发生率显著更高。发现喘息与睡眠不安独立相关（优势比（OR）=2.4）。喘息与入睡困难、夜间觉醒、呼吸暂停以及白天嗜睡和疲倦之间无关联。在对可能的混杂因素进行调整后，存在以下显著关联：打鼾与呼吸暂停（OR = 1.6）、慢性鼻炎与呼吸暂停（OR = 1.6）、打鼾与睡眠不安（OR = 3.2）、慢性鼻炎与睡眠不安（OR = 2.1）以及花粉症与白天疲倦（OR = 4.3）。在对可能的混杂因素进行调整后，喘息与打鼾风险增加相关（OR = 2.8），慢性鼻炎患者打鼾风险也增加（OR = 1.7）。
与无喘息的同龄人相比，喘息儿童的睡眠受到损害，导致白天疲倦的患病率增加。对于这些儿童，应仔细考虑上呼吸道症状，如慢性鼻炎或花粉症，因为它们可能是这些睡眠问题的原因。
