Wang Xiang-xiang, Sun Zi-lin, Yu Jiang-yi
Department of Endocrinology, Zhongda Hospital, Southeast University, Nanjing.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Apr;27(4):315-7.
To investigate the effect of Liuwei Dihuang Soft Capsule(LDSC) and Ginkgo Leaf Tablet (GLT) on serum regulated upon activation, normal T cell expressed and secreted (RANTES) in the patients with diabetes mellitus type 2 (DM2).
Forty patients with early stage DM2 were randomly assigned to two groups, 20 in each group. Based on the conventional treatment with hypoglycemic agents, patients in the treated group were treated with LDSC plus GLT additionally, and those in the placebo group with placebo for 6 months, respectively. The levels of serum RANTES, blood glucose, blood lipids and glycosylated hemoglobin, as well as micro-content of albumin in urine were measured before and after treatment.
In the treated group, the serum level of RANTES decreased significantly after treatment, and it was significantly lower as compared with that in the control group (P < 0.05).
LDSC and GLT can decrease serum RANTES level in patients with DM2. They play a preventive and therapeutic role on diabetic complications by their anti-inflammatory effect.
探讨六味地黄软胶囊（LDSC）和银杏叶片（GLT）对2型糖尿病（DM2）患者血清中受激活调节正常T细胞表达和分泌因子（RANTES）的影响。
将40例早期DM2患者随机分为两组，每组20例。在使用降糖药物常规治疗的基础上，治疗组患者加用LDSC和GLT，安慰剂组患者服用安慰剂，分别治疗6个月。治疗前后检测血清RANTES水平、血糖、血脂、糖化血红蛋白以及尿微量白蛋白含量。
治疗组治疗后血清RANTES水平显著降低，与对照组相比差异有统计学意义（P < 0.05）。
LDSC和GLT可降低DM2患者血清RANTES水平，通过抗炎作用对糖尿病并发症起到防治作用。
