The Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Nanjing, China.
Complement Ther Med. 2018 Oct;40:120-125. doi: 10.1016/j.ctim.2018.08.007. Epub 2018 Aug 27.
To evaluate the impact to oxidative stress, atherosclerosis and macrovascular disease by two proprietary herbal medicines including Ginkgo Leaf Tablets and Liuwei Dihuang Pills in type 2 diabetes.
The recruited 140 type 2 diabetes were randomly divided into the treatment group and control group which were both received basic diabetic management including anti-hyperglycemia, anti-hypertension, life style adjustment and health education etc. Additionally, the treatment group was given both Ginkgo Leaf Tablets and Liuwei Dihuang Pills while the control group was given placebos of Ginkgo Leaf Tablets and Liuwei Dihuang Pills. The relative clinical indexes about macrovascular events occurrence, atherosclerosis degree(IMT levels), oxidative stress in vivo(plasma carboxymethyl lysine(CML) and 8-isoprostane(8-IsoP) levels), plasma glucose, plasma lipid, blood pressure, other drugs usage situations and so on of two groups before and after consecutive 36-month treatment were accurately collected and statistically analyzed.
There were no significant differences of cardiovascular disease, cerebrovascular disease, IMT levels, plasma CML and 8-IsoP levels between the two groups before treatment. After 36-month treatment, the plasma CML and 8-IsoP levels of treatment group were both significantly lower than control group (CML: 312.4 ± 90.4 ng/ml versus 463.5 ± 97.2 ng/ml, P < 0.0001; 8-IsoP: 23.7 ± 9.5 pg/ml versus 62.6 ± 16.1 pg/ml, P < 0.0001) although this improvement was not shared with IMT and macrovascular events.
Ginkgo Leaf Tablets and Liuwei Dihuang Pills are beneficial to oxidative stress which plays important role in diabetic atherosclerosis and macrovascular complications. The preventive and therapeutic values of herbal medicines will be proved in further diabetic complication researches.
评估两种专利草药（银杏叶片和六味地黄丸）对 2 型糖尿病患者氧化应激、动脉粥样硬化和大血管疾病的影响。
将 140 例 2 型糖尿病患者随机分为治疗组和对照组，两组均接受基础糖尿病管理，包括降血糖、降血压、生活方式调整和健康教育等。此外，治疗组给予银杏叶片和六味地黄丸，对照组给予银杏叶片和六味地黄丸安慰剂。连续 36 个月治疗前后，准确收集两组患者大血管事件发生、动脉粥样硬化程度（IMT 水平）、体内氧化应激（血浆羧甲基赖氨酸（CML）和 8-异前列腺素（8-IsoP）水平）、血糖、血脂、血压、其他药物使用情况等相关临床指标，并进行统计学分析。
治疗前两组患者心血管疾病、脑血管疾病、IMT 水平、血浆 CML 和 8-IsoP 水平无统计学差异。治疗 36 个月后，治疗组血浆 CML 和 8-IsoP 水平均显著低于对照组（CML：312.4±90.4ng/ml 比 463.5±97.2ng/ml，P<0.0001；8-IsoP：23.7±9.5pg/ml 比 62.6±16.1pg/ml，P<0.0001），尽管 IMT 和大血管事件没有改善。
银杏叶片和六味地黄丸有利于氧化应激，氧化应激在糖尿病动脉粥样硬化和大血管并发症中起重要作用。草药的预防和治疗价值将在进一步的糖尿病并发症研究中得到证实。
