Kalinina E P, Ivanov E M, Ian'kova V I, Vitkina T I
Ter Arkh. 2007;79(3):15-7.
To characterize cell dysregulation in chronic obstructive pulmonary disease (COPD) at local and systemic levels.
A total of 48 patients with COPD were examined (mean disease duration 11.2 +/- 7.2 years, mean age 58 +/- 4.2 years). Content of glutathione, and activity of glutathione peroxidase, glutathione reductase in whole blood (Novgorodtseva T.P., 2003), catalase in erythrocytes (Karpichenko A.I., 1999) were determined. Products of lipid peroxidation in exhaled breath condensate were defined to reveal diene conjugates of hydroperoxides, ketodienes, coupled trienes (Khyshiktuyev B.S., 1996).
An evident oxidation stress at the local level was revealed in patients with COPD in deficiency of enzymatic antiperoxide link of anti-oxidant defense that is characterized by increased quantity of lipid peroxidation intermediants both in heptane and isopropanol phases.
在局部和全身水平上表征慢性阻塞性肺疾病（COPD）中的细胞失调。
共检查了48例慢性阻塞性肺疾病患者（平均病程11.2±7.2年，平均年龄58±4.2岁）。测定了全血中谷胱甘肽的含量、谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性（诺夫哥罗德采娃T.P.，2003年），红细胞中过氧化氢酶的活性（卡尔皮琴科A.I.，1999年）。测定呼出气冷凝物中的脂质过氧化产物，以揭示氢过氧化物的二烯共轭物、酮二烯、偶联三烯（希什克图耶夫B.S.，1996年）。
慢性阻塞性肺疾病患者在抗氧化防御的酶促抗过氧化物环节缺乏时，在局部水平上出现明显的氧化应激，其特征是庚烷和异丙醇相中脂质过氧化中间体的数量增加。
