[慢性阻塞性肺疾病患者的代谢紊乱]

[Metabolic disorders in patients with chronic obstructive pulmonary disease].

作者信息

Kalinina E P, Ivanov E M, Ian'kova V I, Vitkina T I

出版信息

Ter Arkh. 2007;79(3):15-7.

PMID:17526188

Abstract

AIM

To characterize cell dysregulation in chronic obstructive pulmonary disease (COPD) at local and systemic levels.

MATERIAL AND METHODS

A total of 48 patients with COPD were examined (mean disease duration 11.2 +/- 7.2 years, mean age 58 +/- 4.2 years). Content of glutathione, and activity of glutathione peroxidase, glutathione reductase in whole blood (Novgorodtseva T.P., 2003), catalase in erythrocytes (Karpichenko A.I., 1999) were determined. Products of lipid peroxidation in exhaled breath condensate were defined to reveal diene conjugates of hydroperoxides, ketodienes, coupled trienes (Khyshiktuyev B.S., 1996).

RESULTS

An evident oxidation stress at the local level was revealed in patients with COPD in deficiency of enzymatic antiperoxide link of anti-oxidant defense that is characterized by increased quantity of lipid peroxidation intermediants both in heptane and isopropanol phases.

摘要

目的

在局部和全身水平上表征慢性阻塞性肺疾病（COPD）中的细胞失调。

材料与方法

共检查了48例慢性阻塞性肺疾病患者（平均病程11.2±7.2年，平均年龄58±4.2岁）。测定了全血中谷胱甘肽的含量、谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性（诺夫哥罗德采娃T.P.，2003年），红细胞中过氧化氢酶的活性（卡尔皮琴科A.I.，1999年）。测定呼出气冷凝物中的脂质过氧化产物，以揭示氢过氧化物的二烯共轭物、酮二烯、偶联三烯（希什克图耶夫B.S.，1996年）。