呼出气冷凝物在评估慢性阻塞性肺疾病患者氧化-抗氧化系统中的重要性。

The importance of exhaled air condensate in assessing the oxidant-antioxidant system in patients with chronic obstructive pulmonary disease.

作者信息

Makarevich Aleksandr E, Ivashkevich Dmitry L

机构信息

Department of Internal Diseases N1, Belarusian State Medical University.

出版信息

Wiad Lek. 2003;56(1-2):19-23.

PMID:12901263

Abstract

The aim of this study was to investigate the relationship between selected lipid peroxidation products as markers of oxidative stress and antioxidant defense capacity in exhaled air condensate in comparison to blood and COPD severity. We detected that the increase of lipids peroxidation products in exhaled air condensate (less in blood) was accompanied by the reduction of total antioxidant capacity (antiradical activity and ceruloplasmin) according to the severity of COPD. Thus, the level of malondialdehyde significantly increased both in blood and exhaled air condensate in COPD1,2,3 (by 24%, 86%, 100% and 58%, 92%, 2,3 times respectively). Antiradical activity level was significantly decreased both in blood and exhaled air condensate in patients with COPD2,3 by 24%, 51% and 23.31% respectively. The results of this study clearly demonstrated the imbalance in oxidant-antioxidant system in advanced COPD.

摘要

本研究的目的是调查作为氧化应激标志物的特定脂质过氧化产物与呼出气体冷凝物中的抗氧化防御能力之间的关系，并与血液和慢性阻塞性肺疾病（COPD）严重程度进行比较。我们检测到，根据COPD的严重程度，呼出气体冷凝物中脂质过氧化产物增加（血液中增加较少），同时总抗氧化能力（抗自由基活性和铜蓝蛋白）降低。因此，COPD 1、2、3期患者血液和呼出气体冷凝物中的丙二醛水平均显著升高（分别升高24%、86%、100%和58%、92%、2.3倍）。COPD 2、3期患者血液和呼出气体冷凝物中的抗自由基活性水平分别显著降低24%、51%和23.31%。本研究结果清楚地表明，晚期COPD患者氧化-抗氧化系统失衡。