Fedoseev G B, Petrova M A, Shaĭlieva L O, Kakliugin A P, Zorina M L, Sakharov A N, Pavliukova N O
Ter Arkh. 2007;79(3):37-41.
To evaluate peculiarities of a clinical course and changes in bronchial mucosa in bronchial asthma (BA) patients with chronic obstructive pulmonary disease (COPD) in combination with hyperoxaluria (HOU); informative value of some laboratory and device findings including oxalates assay in bronchial lavage fluid for specification of the diagnosis, role of oxalates in development of obstructive syndrome and choice of optimal therapy.
Oxalates were examined in daily urine, bronchoalveolar lavage fluid and exhaled air condensate of 104 patients with BA and COPD, 77 of which had HOU and an atypical course of bronchial obstruction syndrome.
Conception of airways inflammation in patients with oxalate metabolism disturbances is proposed. It is shown that insoluble oxalates participate in pathogenesis of bronchial obstruction.
Oxalate metabolism disturbances are an important factor in pathogenesis of airways inflammation and development of bronchial obstruction in predisposed patients. Therefore, administration of insoluble oxalates lowering therapy may effectively prevent formation and progression of obstructive pulmonary diseases in this group of patients.
评估合并高草酸尿症（HOU）的慢性阻塞性肺疾病（COPD）的支气管哮喘（BA）患者的临床病程特点及支气管黏膜变化；某些实验室和仪器检查结果（包括支气管灌洗液中草酸盐检测）对明确诊断的参考价值、草酸盐在阻塞性综合征发生中的作用以及最佳治疗方案的选择。
对104例患有BA和COPD的患者的每日尿液、支气管肺泡灌洗液和呼出气冷凝物中的草酸盐进行检测，其中77例患有HOU且支气管阻塞综合征病程不典型。
提出了草酸盐代谢紊乱患者气道炎症的概念。结果表明，不溶性草酸盐参与支气管阻塞的发病机制。
草酸盐代谢紊乱是易感患者气道炎症发病机制和支气管阻塞发展的重要因素。因此，给予降低不溶性草酸盐的治疗可能有效预防该组患者阻塞性肺疾病的形成和进展。
