Suppr超能文献

小梁微旁路支架在青光眼患者中的初步临床经验。

Initial clinical experience with the trabecular micro-bypass stent in patients with glaucoma.

作者信息

Spiegel Detlev, Wetzel Wolfgang, Haffner David S, Hill Richard A

机构信息

Klinik Vincentinum, Ausburg, Germany.

出版信息

Adv Ther. 2007 Jan-Feb;24(1):161-70. doi: 10.1007/BF02850004.

Abstract

This study was undertaken to evaluate the efficiency of a trabecular micro-bypass stent designed to allow direct aqueous drainage from the anterior chamber into Schlemm's canal in patients with glaucoma. In this prospective case series of 6 patients with open-angle glaucoma, the microstent was inserted ab interno under local anesthesia in an ophthalmic operating room. Patients were seen postoperatively at 1 to 2 d, 1 wk, and 1, 2, 6, and 12 mo. All stents were successfully placed within Schlemm's canal. Mean intraocular pressure (IOP) at preoperative baseline was 20.2+/-6.3 mm Hg (range, 14-31 mm Hg). Mean IOP decreased during the immediate postoperative period to approximately 12 to 13 mm Hg and was stabilized at 14 to 15 mm Hg with reduction of medication throughout 1 y of follow-up. No major complications occurred. According to observations reported in this feasibility study, the microstent was effective in reducing IOP and in decreasing the number of glaucoma medications required to control IOP. Implantation procedures were safe, and stents remained in place throughout the follow-up period. None of the complications traditionally associated with filtering surgery were reported. Further research on this stent in a larger group of patients is needed to assess its role in glaucoma therapy.

摘要

本研究旨在评估一种小梁微旁路支架的有效性,该支架旨在使青光眼患者的前房房水直接引流至施莱姆管。在这个包含6例开角型青光眼患者的前瞻性病例系列中,在眼科手术室局部麻醉下经内路插入微支架。术后1至2天、1周以及1、2、6和12个月对患者进行随访。所有支架均成功置入施莱姆管。术前基线平均眼压(IOP)为20.2±6.3 mmHg(范围14 - 31 mmHg)。术后即刻平均眼压降至约12至13 mmHg,并在1年的随访期间通过减少用药稳定在14至15 mmHg。未发生重大并发症。根据该可行性研究报告的观察结果,微支架在降低眼压以及减少控制眼压所需的青光眼药物数量方面有效。植入手术安全,且在整个随访期间支架均保持在位。未报告传统上与滤过手术相关的并发症。需要在更多患者中对该支架进行进一步研究,以评估其在青光眼治疗中的作用。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验