Ohsawa Masaki, Okayama Akira, Okamura Tomonori, Itai Kazuyoshi, Nakamura Motoyuki, Tanno Kozo, Kato Karen, Yaegashi Yumi, Onoda Toshiyuki, Sakata Kiyomi, Ueshima Hirotsugu
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan.
Circ J. 2007 Jun;71(6):814-9. doi: 10.1253/circj.71.814.
The extent to which atrial fibrillation (AF) contributes to mortality in the Japanese general population has not been clarified.
A randomly sampled general population from all over Japan (4,154 men, 5,329 women; age > or =30 years) was enrolled. Single electrocardiogram recordings were taken in the baseline survey. Stroke death, cardiovascular deaths and all-cause deaths during the subsequent 19 years were analyzed by the presence of AF at baseline. Cox's regression analysis was carried out to estimate the hazard ratios (HRs) of each cause of death attributable to AF after adjusting for other risk factors. Prevalence of AF was 0.64% in the study. The observed person-years were 162,980 among persons without AF and 699 among persons with AF. There were 1,919 deaths. Multivariate adjusted HRs for stroke death, cardiovascular death and all-cause death were 2.69, 2.76 and 1.88, respectively (p<0.05). These HRs were 14.7, 9.63 and 4.00 among persons aged 64 years or younger (p<0.05).
AF affects stroke mortality, cardiovascular mortality and all-cause mortality in the Japanese general population. Careful attention should be paid to persons with AF in order to prevent future cardiovascular events.
心房颤动（AF）对日本普通人群死亡率的影响程度尚未明确。
纳入了来自日本各地的随机抽样普通人群（4154名男性，5329名女性；年龄≥30岁）。在基线调查中进行单次心电图记录。根据基线时是否存在AF分析随后19年中的中风死亡、心血管死亡和全因死亡情况。在调整其他危险因素后，进行Cox回归分析以估计AF导致的每种死亡原因的风险比（HRs）。研究中AF的患病率为0.64%。无AF者的观察人年数为162,980，有AF者为699。共有1919例死亡。中风死亡、心血管死亡和全因死亡的多变量调整HRs分别为2.69、2.76和1.88（p<0.05）。在64岁及以下人群中，这些HRs分别为14.7、9.63和4.00（p<0.05）。
AF影响日本普通人群的中风死亡率、心血管死亡率和全因死亡率。应密切关注AF患者以预防未来的心血管事件。
