Hara Tetsuya, Yamada Shinichiro, Hayashi Takatoshi, Ikeda Yoshihiro, Yamashiro Kohei, Mizutani Kazuo, Iwata Sachiyo, Okajima Katsunori, Tsukishiro Yasue, Matsumoto Kensuke, Akagami Takafumi, Kumagai Hiroyuki, Kinugasa Mitsuo, Inoue Michihiko, Murai Naoki, Izawa Ichiro, Kajiya Teishi
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Circ J. 2007 Jun;71(6):911-4. doi: 10.1253/circj.71.911.
The ability to evaluate coronary stenosis using multi-detector computed tomography (MDCT) has been well discussed. In contrast, several studies demonstrated that the plaque burden measured by intravascular ultrasound (IVUS) has a relationship to the risk of cardiovascular events. the accuracy of MDCT was studied to determine plaque and vessel size compared with IVUS.
Fifty-six proximal lesions (American College of Cardiology/American Heart Association classification: segment 1, 5, 6) from 33 patients were assessed using MDCT and IVUS. The plaque and vessel area were measured from the cross-sectional image using both MDCT and IVUS. Eight coronary artery lesions with motion artifacts and heavily calcified plaques were excluded from the analysis. The vessel and lumen size evaluated using MDCT were closely correlated with those evaluated by IVUS (R(2)=0.614, 0.750 respectively). Furthermore, there was a strong correlation between percentage plaque area assessed by MDCT and IVUS (R(2)=0.824).
MDCT can noninvasively quantify coronary atherosclerotic plaque with good correlation compared with IVUS in patients with atherosclerosis.
使用多排螺旋计算机断层扫描（MDCT）评估冠状动脉狭窄的能力已得到充分讨论。相比之下，多项研究表明，血管内超声（IVUS）测量的斑块负荷与心血管事件风险相关。本研究旨在对比IVUS，研究MDCT在确定斑块和血管大小方面的准确性。
对33例患者的56处近端病变（美国心脏病学会/美国心脏协会分类：节段1、5、6）进行了MDCT和IVUS评估。使用MDCT和IVUS从横断面图像测量斑块和血管面积。分析排除了8处有运动伪影和严重钙化斑块的冠状动脉病变。MDCT评估的血管和管腔大小与IVUS评估的结果密切相关（R²分别为0.614和0.750）。此外，MDCT和IVUS评估的斑块面积百分比之间存在很强的相关性（R²=0.824）。
在动脉粥样硬化患者中，MDCT能够无创地定量冠状动脉粥样硬化斑块，且与IVUS具有良好的相关性。
