Department of Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Department of Cardiology, Heart and Vascular Institute, West Virginia University, Morgantown, WV 26506, USA.
Tomography. 2023 Sep 20;9(5):1755-1771. doi: 10.3390/tomography9050140.
We aimed to assess the prevalence of non-calcified plaque (NCP) on computed tomography angiography (CCTA) in symptomatic and asymptomatic individuals. In addition, we seek to compare plaque assessment on CCTA with intravascular ultrasound-virtual histology (IVUS-VH) and to assess the prognostic value of non-calcified plaques (NCPs).
The CCTA can characterize coronary plaques and help quantify burden. Furthermore, it can provide additional prognostic information which can enable further risk stratification of patients.
We performed a broad comprehensive review of the current literature pertaining to CCTA and primarily isolated NCP in symptomatic and asymptomatic patients. In addition, our review included studies correlating plaque on CT with IVUS-VH.
NCP is the initial precursor of calcified plaque and serves as a prominent marker of early coronary atherosclerosis. By detecting NCP during early stages, several measures can be implemented which can alter the evolutionary course of the underlying disease. This can potentially lead to a lower incidence of cardiovascular events.
我们旨在评估有症状和无症状个体计算机断层扫描血管造影（CCTA）上非钙化斑块（NCP）的患病率。此外，我们寻求比较 CCTA 上的斑块评估与血管内超声虚拟组织学（IVUS-VH），并评估非钙化斑块（NCP）的预后价值。
CCTA 可以对冠状动脉斑块进行特征描述，并有助于量化负担。此外，它还可以提供额外的预后信息，从而能够对患者进行进一步的风险分层。
我们对与 CCTA 相关的当前文献进行了广泛全面的综述，主要关注有症状和无症状患者的单纯 NCP。此外，我们的综述还包括了将 CT 上的斑块与 IVUS-VH 相关联的研究。
NCP 是钙化斑块的初始前体，是早期冠状动脉粥样硬化的显著标志物。通过在早期阶段检测 NCP，可以采取几种措施来改变潜在疾病的演变过程。这可能会导致心血管事件的发生率降低。
