Yeh Chih-Ching, Hou Ming-Feng, Tsai Shih-Meng, Lin Shu-Kai, Hsiao Jen-Kuei, Huang Jung-Chih, Wang Li-Hsuan, Wu Szu-Hsien, Hou Linda Ann, Ma Hsu, Tsai Li-Yu
Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Clin Chim Acta. 2005 Nov;361(1-2):104-11. doi: 10.1016/j.cccn.2005.05.002.
Reactive oxygen species (ROS), including superoxide anion radical (O2(-)), plays an important role in carcinogenesis. The human body has developed different antioxidant systems to defend against free radical attacks. We investigated the changes of the antioxidant status in the blood of patients with breast cancer.
The O2(-) generation and the levels of malondialdehyde (MDA) were measured as an index of lipid peroxidation along with the examination of the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRx), the levels of reduced glutathione (GSH), oxidized glutathione (GSSG), and vitamins A, C, and E.
The results showed that the levels of O2(-) and MDA, and the activities of antioxidant enzymes in the blood of the patients with breast cancer were significantly higher than the controls. However, the levels of vitamin C, GSH, GSSG and ratio of GSH/GSSG in the blood of the patients with breast cancer were significantly decreased compared to control subjects.
Oxidative stress may be involved in breast cancer. The increased activities of erythrocyte antioxidant enzymes may be a compensatory upregulation in response to the increased oxidative stress.
活性氧（ROS），包括超氧阴离子自由基（O2(-)），在致癌过程中起重要作用。人体已发展出不同的抗氧化系统来抵御自由基攻击。我们研究了乳腺癌患者血液中抗氧化状态的变化。
测量O2(-)生成量和丙二醛（MDA）水平作为脂质过氧化指标，同时检测超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）、谷胱甘肽还原酶（GRx）的活性，以及还原型谷胱甘肽（GSH）、氧化型谷胱甘肽（GSSG）和维生素A、C、E的水平。
结果显示，乳腺癌患者血液中O2(-)和MDA水平以及抗氧化酶活性显著高于对照组。然而，与对照组相比，乳腺癌患者血液中维生素C、GSH、GSSG水平及GSH/GSSG比值显著降低。
氧化应激可能与乳腺癌有关。红细胞抗氧化酶活性增加可能是对氧化应激增加的一种代偿性上调。
