Wang Mengying, Meng Ruoyu, Gao Yan, Huang Junxia, Li Tianlan, Mao Chunxia, Liu Shanshan, Xu Yujie, Xu Han, Feng Xianqi
Department of Hematology Faculty of Medicine Qingdao University The Affiliated Hospital of Qingdao University Qingdao China.
Department of Hematology The Affiliated Hospital of Qingdao University Qingdao China.
Clin Case Rep. 2022 Mar 10;10(3):e05538. doi: 10.1002/ccr3.5538. eCollection 2022 Mar.
To explore the clinical characteristics, diagnosis, and treatment of chronic lymphocytic leukemia with secondary pancytopenia. Here, a case of pancytopenia secondary to chronic lymphocytic leukemia is reported. Additionally, a review of relevant chronic lymphocytic leukemia literature was conducted to summarize its diagnosis, clinical characteristics, treatment history, and experience. After treatment with cyclosporine A, the patient's chronic lymphocytic leukemia continued to resolve, and hematopoiesis returned to normal. Cyclosporine A therapy resulted in improved patient outcomes. However, the mechanism by which cyclosporine A rebuilds the immune microenvironment and its antileukemia effect in the body remains to be studied.
探讨慢性淋巴细胞白血病继发全血细胞减少的临床特征、诊断及治疗方法。本文报道1例慢性淋巴细胞白血病继发全血细胞减少的病例。此外，对慢性淋巴细胞白血病的相关文献进行了回顾，以总结其诊断、临床特征、治疗史及经验。经环孢素A治疗后，患者的慢性淋巴细胞白血病持续缓解，造血功能恢复正常。环孢素A治疗改善了患者的预后。然而，环孢素A重建免疫微环境及其在体内的抗白血病作用机制仍有待研究。
