基于酰基赖氨酸低聚物的改良抗菌肽。
Improved antimicrobial peptides based on acyl-lysine oligomers.
作者信息
Radzishevsky Inna S, Rotem Shahar, Bourdetsky Dmitry, Navon-Venezia Shiri, Carmeli Yehuda, Mor Amram
机构信息
Department of Biotechnology & Food Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel.
出版信息
Nat Biotechnol. 2007 Jun;25(6):657-9. doi: 10.1038/nbt1309. Epub 2007 May 27.
We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.
我们描述了一类拟肽寡聚物，它们在小鼠体内表现出快速、非溶血性、广谱杀菌特性，且不会诱导耐药性的产生。这些寡聚物含有酰基链，可阻止稳定二级结构的形成。相对于传统抗菌肽，这种设计在体内疗效和安全性方面似乎具有优势，并且可能为肽类抗生素的开发提供一个便利的平台。
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