Breuleux M
Novartis Institutes for Biomedical Research (NIBR), Oncology, WKL-125.12.59, Klybeckstrasse 141, 4002, Basel, Switzerland.
Cell Mol Life Sci. 2007 Sep;64(18):2358-77. doi: 10.1007/s00018-007-7120-0.
Heregulin (HRG) is a soluble secreted growth factor, which, upon binding and activation of ErbB3 and ErbB4 transmembrane receptor tyrosine kinases, is involved in cell proliferation, invasion, survival and differentiation of normal and malignant tissues. The HRG gene family consists of four members: HRG-1, HRG-2, HRG-3 and HRG-4, of which a multitude of different isoforms are synthesized by alternative exon splicing, showing various tissue distribution and biological activities. Disruption of the physiological balance between HRG ligands and their ErbB receptors is implicated in the formation of a variety of human cancers. The general mechanisms involved in HRG-induced tumorigenesis is discussed.
Heregulin（HRG）是一种可溶性分泌型生长因子，它在与ErbB3和ErbB4跨膜受体酪氨酸激酶结合并激活后，参与正常组织和恶性组织的细胞增殖、侵袭、存活及分化过程。HRG基因家族由四个成员组成：HRG-1、HRG-2、HRG-3和HRG-4，通过外显子选择性剪接可合成多种不同的异构体，表现出不同的组织分布和生物学活性。HRG配体与其ErbB受体之间生理平衡的破坏与多种人类癌症的形成有关。本文讨论了HRG诱导肿瘤发生的一般机制。
