Wasyłyszyn Tomasz, Kozłowski Wojciech, Zabielski Stanisław Leopold
Dermatology Clinic, Military Medical Institute, Szaserow 128 st, 00-909 Warsaw, Poland.
Arch Dermatol Res. 2007 Aug;299(5-6):231-7. doi: 10.1007/s00403-007-0759-4. Epub 2007 May 26.
For many years, the role of T lymphocytes was hypothesized as being a major factor responsible for hair loss in alopecia areata (a.a.). While numerous lymphocytic populations were found around hair bulbs, changes in their distribution patterns in the skin during the course and recovery of the disease remain unknown. In the present study, distribution of CD8 lymphocytes in biopsies obtained from a.a. patients was measured before and during treatment using diphencyprone (DCP). Results show about a 600% increase in the number of CD8 lymphocytes under the epithelium and about a 250% increase around hair bulbs and other epidermal appendages during the study. These results were more significant in a group, which had good clinical response to the treatment. No change in the quantity of CD8 lymphocytes was observed around the blood vessels. Since CD8 lymphocytes are considered to be directly involved in the hair destruction process in a.a., their increased number around hair bulbs followed by hair regrowth may suggest that during DCP treatment they regain normal reactivity to hair antigens.
多年来，T淋巴细胞的作用被假定为斑秃（AA）脱发的主要因素。虽然在毛囊周围发现了众多淋巴细胞群体，但在疾病过程和恢复期间它们在皮肤中的分布模式变化仍不清楚。在本研究中，使用二苯环丙烯酮（DCP）对AA患者活检组织中CD8淋巴细胞的分布在治疗前和治疗期间进行了测量。结果显示，在研究期间，上皮下CD8淋巴细胞数量增加了约600%，毛囊和其他表皮附属器周围增加了约250%。这些结果在对治疗有良好临床反应的一组中更为显著。在血管周围未观察到CD8淋巴细胞数量的变化。由于CD8淋巴细胞被认为直接参与AA中的毛发破坏过程，它们在毛囊周围数量增加随后毛发再生可能表明，在DCP治疗期间，它们恢复了对毛发抗原的正常反应性。
