Ribi K, Bernhard J, Rufibach K, Thürlimann B, von Moos R, Ruhstaller T, Glaus A, Böhme C
International Breast Cancer Study Group, Coordinating Center, Effingerstrasse 40, 3008, Bern, Switzerland.
Support Care Cancer. 2007 Dec;15(12):1349-56. doi: 10.1007/s00520-007-0258-3. Epub 2007 May 26.
To investigate the self-reported symptoms related to endocrine therapy in women with early or advanced breast cancer and the impact of these symptoms on quality of life (QL) indicators.
Symptom occurrence was assessed by the Checklist for Patients on Endocrine Therapy (C-PET) and symptom intensity was assessed by linear analogue self-assessment (LASA) indicators. Patients also responded to global LASA indicators for physical well-being, mood, coping effort and treatment burden. Associations between symptoms and these indicators were analysed by linear regression models.
Among 373 women, the distribution of symptom intensity showed considerable variation in patients reporting a symptom as present. Even though patients recorded a symptom as absent, some patients reported having experienced that symptom when responding to symptom intensity, as seen for decreased sex drive, tiredness and vaginal dryness. Six of 13 symptoms and lower age had a detrimental impact on the global indicators, particularly tiredness and irritability.
Patients' experience of endocrine symptoms needs to be considered both in patient care and research, when interpreting the association between symptoms and QL.
调查早期或晚期乳腺癌女性患者中与内分泌治疗相关的自我报告症状，以及这些症状对生活质量（QL）指标的影响。
通过内分泌治疗患者检查表（C-PET）评估症状的发生情况，并通过线性模拟自我评估（LASA）指标评估症状强度。患者还对身体状况、情绪、应对努力和治疗负担的整体LASA指标做出回应。通过线性回归模型分析症状与这些指标之间的关联。
在373名女性患者中，症状强度分布显示，报告出现某种症状的患者存在相当大的差异。即使患者记录某种症状不存在，但在回应症状强度时，一些患者报告曾经历过该症状，如性欲减退、疲劳和阴道干燥。13种症状中的6种以及年龄较小对整体指标有不利影响，尤其是疲劳和易怒。
在解释症状与生活质量之间的关联时，无论是在患者护理还是研究中，都需要考虑患者的内分泌症状体验。
