Glaus A, Boehme Ch, Thürlimann B, Ruhstaller T, Hsu Schmitz S F, Morant R, Senn H J, von Moos R
Tumorzentrum ZeTuP, Diagnostik, Behandlung und Prävention, St. Gallen, Switzerland.
Ann Oncol. 2006 May;17(5):801-6. doi: 10.1093/annonc/mdl030. Epub 2006 Feb 28.
Hormonal treatment for women with breast cancer is frequently proposed in the adjuvant as well as in the palliative setting. Therefore, many women are confronted with early menopause and prolonged oestrogen deprivation and consequently with a variety of quality of life issues, such as menopausal symptoms and fatigue.
It was the aim of this study to explore the occurrence and frequency of menopausal symptoms in women with breast cancer, undergoing hormonal cancer treatment and to investigate their relationship with fatigue. A cross-sectional, quantitative approach was used in this multi-centre study. The Checklist for Patients with Endocrine Therapy (C-PET) and the International Breast Cancer Study Group (IBCSG) Linear Analogue Scales for patients with endocrine treatment were used. Descriptive statistics, as well as cluster analyses were performed.
Most frequent menopausal symptoms involved hot flashes/sweats, tiredness, weight gain, vaginal dryness and decreased sexual interest. There were significant differences between the fatigued and the non-fatigued population regarding the intensity of menopausal symptoms, emotional irritability and general coping. Cluster analyses supported a menopausal symptom cluster.
Fatigue accompanies menopausal symptoms and an association can be expected. Methods for routine screening for menopausal symptoms, including fatigue, are suggested as a relevant research issue in women with breast cancer undergoing hormonal treatment.
乳腺癌女性的激素治疗常用于辅助治疗和姑息治疗。因此，许多女性面临早期绝经和长期雌激素缺乏，进而出现各种生活质量问题，如更年期症状和疲劳。
本研究旨在探讨接受激素癌症治疗的乳腺癌女性更年期症状的发生情况和频率，并研究这些症状与疲劳之间的关系。本多中心研究采用横断面定量研究方法。使用了内分泌治疗患者检查表（C-PET）和国际乳腺癌研究组（IBCSG）内分泌治疗患者线性模拟量表。进行了描述性统计和聚类分析。
最常见的更年期症状包括潮热/盗汗、疲劳、体重增加、阴道干燥和性兴趣降低。在更年期症状强度、情绪易怒和总体应对方面，疲劳人群和非疲劳人群之间存在显著差异。聚类分析支持更年期症状聚类。
疲劳与更年期症状相伴，两者之间可能存在关联。建议将包括疲劳在内的更年期症状常规筛查方法作为接受激素治疗的乳腺癌女性的一个相关研究问题。
