Saurenmann R K, Rose J B, Tyrrell P, Feldman B M, Laxer R M, Schneider R, Silverman E D
Zurich University Children's Hospital, Zurich, Switzerland.
Arthritis Rheum. 2007 Jun;56(6):1974-84. doi: 10.1002/art.22709.
To study the influence of ethnicity on the risk of developing juvenile idiopathic arthritis (JIA) in a multiethnic community of patients with unrestricted access to health care.
A questionnaire on ethnicity was distributed to all patients with JIA being followed up at the Hospital for Sick Children in Toronto, Ontario, Canada. Of 1,082 patients, 859 (79.4%) responded to the questionnaire. To calculate the relative risk (RR) of developing JIA in this study cohort, the results were compared with data from the age-matched general population of the Toronto metropolitan area (TMA) as provided in the 2001 census from Statistics Canada.
European descent was reported by 69.7% of the patients with JIA compared with a frequency of 54.7% in the TMA general population, whereas a statistically significantly lower than expected percentage of the patients with JIA reported having black, Asian, or Indian subcontinent origin. Children of European origin had a higher RR for developing any of the JIA subtypes except polyarticular rheumatoid factor (RF)-positive JIA, and were particularly more likely to develop the extended oligoarticular and psoriatic subtypes. A higher frequency of enthesitis-related JIA was observed among patients of Asian origin, while those of black origin or native North American origin were more likely to develop polyarticular RF-positive JIA.
In this multiethnic cohort, European descent was associated with a significantly increased risk of developing JIA, and the distribution of JIA subtypes differed significantly across ethnic groups.
在一个可不受限制获得医疗保健的多民族患者群体中，研究种族对青少年特发性关节炎（JIA）发病风险的影响。
向加拿大安大略省多伦多市病童医院正在接受随访的所有JIA患者发放一份关于种族的问卷。在1082名患者中，859名（79.4%）回复了问卷。为计算本研究队列中患JIA的相对风险（RR），将结果与加拿大统计局2001年人口普查提供的多伦多市区（TMA）年龄匹配的普通人群数据进行比较。
69.7%的JIA患者报告有欧洲血统，而TMA普通人群中的这一比例为54.7%，然而，报告有黑人、亚洲或印度次大陆血统的JIA患者百分比在统计学上显著低于预期。除多关节型类风湿因子（RF）阳性JIA外，欧洲血统的儿童患任何JIA亚型的RR更高，尤其更易患扩展性少关节型和银屑病型亚型。在亚洲血统患者中观察到与附着点炎相关的JIA频率较高，而黑人血统或北美原住民血统的患者更易患多关节型RF阳性JIA。
在这个多民族队列中，欧洲血统与患JIA的风险显著增加相关，且JIA亚型的分布在不同种族群体中存在显著差异。
