Kobayashi Hisataka, Hama Yukihiro, Koyama Yoshinori, Barrett Tristan, Regino Celeste A S, Urano Yasuteru, Choyke Peter L
Molecular Imaging Program and Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-1088, USA.
Nano Lett. 2007 Jun;7(6):1711-6. doi: 10.1021/nl0707003. Epub 2007 May 26.
Quantum dots can be used to perform multicolor images with high fluorescent intensity and are of a nanosize suitable for lymphatic imaging via direct interstitial injection. Here simultaneous multicolor in vivo wavelength-resolved spectral fluorescence lymphangiography is shown using five quantum dots with similar physical sizes but different emission spectra. This allows noninvasive and simultaneous visualization of five separate lymphatic flows draining and may have implications for predicting the route of cancer metastasis into the lymph nodes.
量子点可用于生成具有高荧光强度的多色图像，其纳米尺寸适合通过直接间质注射进行淋巴成像。本文展示了使用五个物理尺寸相似但发射光谱不同的量子点进行体内多色波长分辨光谱荧光淋巴管造影。这使得能够无创且同时可视化五条引流的独立淋巴流，可能对预测癌症转移至淋巴结的路径具有重要意义。
