Huang Jee-Fu, Dai Chia-Yen, Hwang Shang-Jyh, Ho Chi-Kung, Hsiao Pi-Jung, Hsieh Ming-Yen, Lee Li-Po, Lin Zu-Yau, Chen Shinn-Chern, Hsieh Ming-Yuh, Wang Liang-Yen, Shin Shyi-Jang, Chang Wen-Yu, Chuang Wan-Long, Yu Ming-Lung
Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Am J Gastroenterol. 2007 Jun;102(6):1237-43. doi: 10.1111/j.1572-0241.2007.01181.x.
There is growing evidence with regard to the association between hepatitis C virus (HCV) infection and type 2 diabetes mellitus (T2DM). However, the mutual link and related virological implication have not been fully clarified. The impact of hepatitis B virus (HBV) infection on the epidemiological link remains unclear. This study aimed to elucidate the link between T2DM and viral hepatitis infections, especially HCV infection. It also aimed to analyze the associated virological characteristics and implication.
Cross-sectional analysis of a computer-sampling survey among 10,975 participants (aged 40-65 yr) was performed in an area endemic for HBV and HCV infections in Taiwan. Outcome measures included prevalence of T2DM among different groups of viral hepatitis infection, and comparison of related biochemical and virological profiles.
Of 10,975 participants studied, 9,932 eligible participants were analyzed. The prevalence of T2DM, seropositivity for HBV surface antigen (HBsAg) and HCV antibodies (anti-HCV), and HCV viremia was 12.5%, 13.1%, 6.5%, and 4.8%, respectively. Prevalence of HCV viremia showed significant difference between T2DM and non-T2DM subjects (6.9% vs 4.5%, P<0.001), whereas anti-HCV seropositivity showed borderline significance (7.8% vs 6.3%, P=0.047). There was no HCV genotype-specific difference between HCV genotype 1 and 2 in the association with T2DM. On the other side, the prevalence of HBsAg (+) did not differ between T2DM and non-T2DM subjects (12.5% vs 13.9%, P=0.19). The prevalence of T2DM among HCV viremic subjects (18.0%, 86/478) was significantly higher than HBsAg (+) subjects (11.4%, 155/1,363, P=0.001) and those negative for both viral hepatitis markers (12.5%, 997/8,004, P=0.001). Multivariate logistic regression analyses showed that HCV viremia was the leading significant factor associated with T2DM, followed by male gender, hypertension, body mass index, and age.
HBV infection did not increase the association with T2DM. A significant mutual link between T2DM and HCV viremia existed in this HBV/HCV endemic area. There was no HCV genotype-specific difference between HCV genotype 1 and 2 in the association with T2DM.
关于丙型肝炎病毒（HCV）感染与2型糖尿病（T2DM）之间的关联，证据越来越多。然而，两者之间的相互联系及相关病毒学意义尚未完全阐明。乙型肝炎病毒（HBV）感染对这种流行病学联系的影响仍不清楚。本研究旨在阐明T2DM与病毒性肝炎感染之间的联系，尤其是HCV感染。本研究还旨在分析相关的病毒学特征及意义。
在台湾HBV和HCV感染流行地区，对10975名参与者（年龄40 - 65岁）进行计算机抽样调查的横断面分析。观察指标包括不同病毒性肝炎感染组中T2DM的患病率，以及相关生化和病毒学指标的比较。
在研究的10975名参与者中，对9932名符合条件的参与者进行了分析。T2DM、HBV表面抗原（HBsAg）血清阳性、HCV抗体（抗 - HCV）及HCV病毒血症的患病率分别为12.5%、13.1%、6.5%和4.8%。HCV病毒血症的患病率在T2DM和非T2DM受试者之间存在显著差异（6.9%对4.5%，P<0.001），而抗 - HCV血清阳性具有临界显著性（7.8%对6.3%，P = 0.047）。在与T2DM的关联中，HCV基因1型和2型之间没有基因型特异性差异。另一方面，HBsAg（+）的患病率在T2DM和非T2DM受试者之间没有差异（12.5%对13.9%，P = 0.19）。HCV病毒血症受试者中T2DM的患病率（18.0%，86/478）显著高于HBsAg（+）受试者（11.4%，155/1363，P = 0.001）和两种病毒性肝炎标志物均为阴性的受试者（12.5%，997/8004，P = 0.001）。多因素逻辑回归分析表明，HCV病毒血症是与T2DM相关的主要显著因素，其次是男性、高血压、体重指数和年龄。
HBV感染并未增加与T2DM的关联。在这个HBV/HCV流行地区，T2DM与HCV病毒血症之间存在显著的相互联系。在与T2DM的关联中，HCV基因1型和2型之间没有基因型特异性差异。
Zotero 插件