Department of Dermatology, Vanderbilt Medical Center, Nashville, Tennessee, USA.
J Am Acad Dermatol. 2012 Apr;66(4):680-6. doi: 10.1016/j.jaad.2011.10.011. Epub 2011 Nov 8.
Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory disorder of unknown origin characterized by pustules, erosions, and crusting in areas of alopecia that tend to be atrophic, actinically damaged, or both. The most common treatments reported include antibiotics and topical anti-inflammatories, which can be ineffective. In the search for effective treatment for EPDS, we share our experience with topical dapsone 5% gel.
We present 4 patients with EPDS, all with classic clinical presentations and histologic findings of EPDS, who had failed a variety of treatments including oral, intralesional, or topical steroids, tacrolimus, and antibiotics. All patients demonstrated rapid improvement or resolution with topical dapsone 5% gel.
Our experience and success with topical dapsone for EPDS is observational and not the result of a randomized controlled trial.
Our observations demonstrate topical dapsone 5% gel to be a novel, safe, and efficacious therapeutic alternative for mild to moderate EPDS.
头皮侵蚀性脓疱病（EPDS）是一种不明原因的炎症性疾病，其特征为脱发区出现脓疱、糜烂和结痂，这些区域往往呈萎缩性、光损伤性或两者兼有。据报道，最常用的治疗方法包括抗生素和局部抗炎药，但这些方法可能无效。为了寻找 EPDS 的有效治疗方法，我们分享了使用 5%达普司特凝胶的经验。
我们介绍了 4 例 EPDS 患者，所有患者均具有典型的临床表现和 EPDS 的组织学表现，他们对包括口服、皮损内或局部类固醇、他克莫司和抗生素在内的多种治疗方法均无效。所有患者均表现出快速改善或局部达普司特 5%凝胶的消退。
我们使用局部达普司特治疗 EPDS 的经验和疗效是观察性的，而不是随机对照试验的结果。
我们的观察结果表明，5%达普司特凝胶是治疗轻度至中度 EPDS 的一种新颖、安全且有效的治疗选择。
