Espinosa Bosch M, Ruiz Sánchez A J, Sánchez Rojas F, Bosch Ojeda C
Department of Pharmacy, General Hospital, University Hospital Virgen del Rocío, Manuel Siurot s/n, 41013 Seville, Spain.
J Pharm Biomed Anal. 2007 Aug 15;44(4):831-44. doi: 10.1016/j.jpba.2007.04.022. Epub 2007 Apr 24.
Omeprazole, a gastric acid pump inhibitor, dose-dependently controls gastric acid secretion; the drug has greater antisecretory activity than histamine H(2)-receptor antagonists. Omeprazole has been determined in formulations and biological fluids by a variety of methods such as spectrophotometry, high-performance liquid chromatography with ultraviolet detection and liquid chromatography coupled with tandem mass spectrometry. The overview includes the most relevant analytical methodologies used in its determination since the origin still today.
奥美拉唑是一种胃酸泵抑制剂，能剂量依赖性地控制胃酸分泌；该药物的抑酸活性比组胺H₂受体拮抗剂更强。已通过多种方法（如分光光度法、带紫外检测的高效液相色谱法以及液相色谱-串联质谱法）对制剂和生物流体中的奥美拉唑进行测定。本综述涵盖了自其问世至今用于测定该药物的最相关分析方法。
