Shahrokhian Saeed, Ghalkhani Masoumeh, Bayat Maryam, Ghorbani-Bidkorbeh Fatemeh
Department of Chemistry, Sharif University of Technology, Tehran, Iran . ; Institute for Nanoscience and Technology, Sharif University of Technology, Tehran, Iran .
Department of Chemistry, Faculty of Science, Shahid Rajaee Teacher Training University, Lavizan, Tehran, Iran .
Iran J Pharm Res. 2015 Spring;14(2):465-71.
The voltammetric performance of edge-plane pyrolytic graphite (EPG) electrode via adsorptive stripping voltammetry was investigated for study of the electrochemical behavior of omeprazole (OMZ) in aqueous solution. The results revealed that the oxidation of OMZ is an irreversible pH-dependent process that proceeds with the transfer of one electron and one proton in an adsorption-controlled mechanism. The determination conditions, such as the pH values of the supporting electrolyte, accumulation time and scan rate were optimized. Simplicity, high reproducibility and low detection limit (3 nM) of the electrode response as well as wide linear range (0.01 to 4.0 µM) can be stated as significant features of this electrode. The EPG electrode was successfully applied for the determination of OMZ in pharmaceutical formulations and satisfactory results were obtained.
通过吸附溶出伏安法研究了边缘平面热解石墨（EPG）电极的伏安性能，以研究奥美拉唑（OMZ）在水溶液中的电化学行为。结果表明，OMZ的氧化是一个不可逆的pH依赖性过程，在吸附控制机制下伴随着一个电子和一个质子的转移。优化了诸如支持电解质的pH值、富集时间和扫描速率等测定条件。电极响应的简单性、高重现性和低检测限（3 nM）以及宽线性范围（0.01至4.0 μM）可被视为该电极的显著特征。EPG电极成功应用于药物制剂中OMZ的测定，并获得了满意的结果。
