Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas, UNESP-Univ Estadual Paulista, Araraquara-SP, Brazil.
Ther Drug Monit. 2010 Oct;32(5):550-9. doi: 10.1097/FTD.0b013e3181eea55a.
Glimepiride is an oral antidiabetic drug in the sulfonylurea class, which is widely used in treatment of Type 2 diabetes and it is currently available in more than 60 countries worldwide. As a result of the importance of this oral hypoglycemic agent in the treatment of noninsulin-dependent diabetes mellitus, this work aims to compile the published analytical methods reported so far in the literature for determination of glimepiride in biologic samples and pharmaceutical formulations. Techniques like high-performance liquid chromatography with ultraviolet, array-diode, mass spectroscopy, evaporative light scattering and charged aerosol detections, liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry, liquid chromatography-electrospray ionization-tandem mass spectrometry, semimicrobore high-performance liquid chromatography with column-switching, micellar electrokinetic chromatography, high-performance thin layer chromatography, polarography, and spectrophotometry have been used for analysis, from which it can be seen that high-performance liquid chromatography methods have been used most extensively.
格列美脲是一种磺酰脲类口服降糖药，广泛用于治疗 2 型糖尿病，目前在全球 60 多个国家使用。由于这种口服降糖药在治疗非胰岛素依赖型糖尿病中的重要性，本工作旨在编译迄今为止文献中报道的用于测定生物样品和药物制剂中格列美脲的已发表分析方法。用于分析的技术包括高效液相色谱法（带紫外、阵列二极管、质谱、蒸发光散射和带电气溶胶检测）、大气压化学电离-质谱法、电喷雾串联质谱法、带柱切换的半微高效液相色谱法、胶束电动色谱法、高效薄层色谱法、极谱法和分光光度法，从中可以看出，高效液相色谱法应用最广泛。
