Bosch M Espinosa, Sánchez A J Ruiz, Rojas F Sánchez, Ojeda C Bosch
Department of Pharmacy, General Hospital, University Hospital Virgen del Rocío, Manuel Siurot s/n, 41013 Sevilla, Spain.
J Pharm Biomed Anal. 2008 Jul 15;47(3):451-9. doi: 10.1016/j.jpba.2008.01.047. Epub 2008 Feb 12.
cis-Diamminedichloroplatinum(II) (cisplatin) is a important chemotherapeutic drug for cancer treatment since 1978. Unfortunately, because of the severe side-effects like nephrotoxicity, ototoxicity, etc., they are administered in small doses at low concentration establishing the maximum limit dosage to 100 mg/m(2) (21 days). A variety of analytical methods have been proposed for the determination of cisplatin in biological fluids and tissues that permit the accurate determination at or below the part per billion level in the native sample. The purpose of the current review is to provide a systematic survey of the latest analytical techniques for the determination of cisplatin in biological samples.
顺二氯二氨合铂（II）（顺铂）自1978年以来一直是癌症治疗的重要化疗药物。不幸的是，由于存在肾毒性、耳毒性等严重副作用，顺铂以低浓度小剂量给药，最大限量为100mg/m²（21天）。人们已经提出了多种分析方法用于测定生物体液和组织中的顺铂，这些方法能够在天然样品中准确测定十亿分之一及以下水平的顺铂。本综述的目的是对测定生物样品中顺铂的最新分析技术进行系统概述。
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