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马耳他群岛的皮肤黑色素瘤:2000 - 2004年

Cutaneous melanoma in the Maltese Islands: 2000-2004.

作者信息

Dalmas Miriam, England Kathleen, Boffa Michael J, Degaetano James, Gatt Paul

机构信息

Department of Health Information, 95, Guardamangia Hill, Guardamangia, Malta.

出版信息

Eur J Cancer. 2007 Jul;43(10):1604-10. doi: 10.1016/j.ejca.2007.04.013. Epub 2007 May 25.

Abstract

This study aimed to, prospectively, over the 5-year period 2000-2004, accurately determine features of cutaneous melanoma in the Maltese Islands. Data from clinicians were supplemented by histology reports, and where necessary, histology slides were reviewed. Information collected included demographic details including age and gender, anatomical site, Clark's level, Breslow thickness and clinico-pathological melanoma type. During the study period the age-standardised (European Standard Population) rates for invasive melanoma were 8.81 per 100,000 (males) and 7.29 per 100,000 (females) and increased with age. By the end of the study, information on 166 cases of primary invasive cutaneous malignant melanoma were collected. The commonest site affected in males was the trunk (54%) and in females the lower limbs (41%). Overall, 33.8% of invasive melanomas had a Breslow thickness >1.5mm. The initial melanoma excision was performed by a dermatologist in 68.2% and plastic surgeon in 20.8%. More cases presented in late spring and summer, particularly in females. Melanoma incidence in Malta is lower than that in high-incidence countries and northern Europe and is similar to that in southern Europe. However, incidence appears to be increasing and a relatively high proportion of patients present with thick lesions emphasising the importance of continued efforts to diagnose cases earlier.

摘要

本研究旨在前瞻性地确定2000年至2004年这5年期间马耳他群岛皮肤黑色素瘤的特征。临床医生提供的数据由组织学报告补充,必要时还会复查组织学切片。收集的信息包括人口统计学细节,如年龄和性别、解剖部位、克拉克分级、 Breslow厚度以及临床病理黑色素瘤类型。在研究期间,侵袭性黑色素瘤的年龄标准化(欧洲标准人口)发病率为每10万人中8.81例(男性)和每10万人中7.29例(女性),且随年龄增长而上升。到研究结束时,共收集了166例原发性侵袭性皮肤恶性黑色素瘤的信息。男性中最常受累的部位是躯干(54%),女性是下肢(41%)。总体而言,33.8%的侵袭性黑色素瘤Breslow厚度>1.5mm。最初的黑色素瘤切除术由皮肤科医生进行的占68.2%,由整形外科医生进行的占20.8%。更多病例出现在晚春和夏季,尤其是女性。马耳他的黑色素瘤发病率低于高发病率国家和北欧,与南欧相似。然而,发病率似乎在上升,且有相对较高比例的患者表现为厚病变,这凸显了继续努力更早诊断病例的重要性。

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