Wentz A C, Jones G S, Sapp K
Obstet Gynecol. 1976 Mar;47(3):309-18.
Patterns of gonadotorpin output were studied in normal individuals and in patients with menstrual dysfunction by radioimmunoassay measurement of LH and FSH output in samples taken every 20 minutes for 6-8 hours, and following administration of synthetic luteinizing hormone releasing hormone (LRH). Follicular phase LH pulses occurred every 1-2 hours, whereas those in the luteal phase occurred less frequently and with higher amplitude. FSH output was irregular, and had no correlation with LH dynamics. In anorixia nervosa, pulsatile LH activity was minimal, and the response to LRH variable, correlating somewhat with the clinical status of the patient. Pulsatile LH activity was observed in patients with postpill and postpartum amenorrhea, and also in one individual with a probable prolactin-producing pituitary tumor. Patients with polycystic ovarian disease had obvious LH pulsatile activity, with a greater amplitude and frequency than seen in the luteal phase, and a decrease in percentage increment, suggesting some difference in the hypothalamic-pituitary control mechanisms under these conditions. The character and pattern of the LH pulsatile activity does vary with different forms of menstrual dysfunction and may be predictive of the LRH response when considered in relation to the LH baseline values. Pulsatile LH activity, analyzed in conjunction with response patterns following LRH stimulation, may reflect the degree of hypothalamic dysfunction.
通过放射免疫分析法测定正常个体和月经功能紊乱患者的促性腺激素输出模式。每20分钟采集一次样本，持续6 - 8小时，并在给予合成促黄体生成素释放激素（LRH）后进行测定。卵泡期促黄体生成素（LH）脉冲每1 - 2小时出现一次，而黄体期的脉冲出现频率较低且幅度较大。促卵泡生成素（FSH）输出不规则，与LH动态无关。在神经性厌食症中，LH的脉冲活动最小，对LRH的反应可变，与患者的临床状态有一定相关性。在服用避孕药后闭经和产后闭经的患者中观察到LH脉冲活动，在一名可能患有分泌催乳素的垂体瘤患者中也观察到了这种活动。多囊卵巢疾病患者有明显的LH脉冲活动，其幅度和频率高于黄体期，且百分比增加值降低，提示在这些情况下下丘脑 - 垂体控制机制存在一些差异。LH脉冲活动的特征和模式确实因月经功能紊乱的不同形式而异，并且在与LH基线值相关联时可能预测对LRH的反应。结合LRH刺激后的反应模式分析LH脉冲活动，可能反映下丘脑功能障碍的程度。
