Sasaki J, Motobu M, Nabeshima Y, Shoji M, Mesaki N, Iwasaki H, Asano K, Eda M
Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki.
Nihon Sanka Fujinka Gakkai Zasshi. 1991 Apr;43(4):437-42.
In athletic women menstrual disorders such as luteal insufficiency, oligomenorrhea and amenorrhea are often seen. It has been suggested that such disorders may be related to hypothalamic-pituitary axis insufficiency caused by physical activity. To investigate the mechanism by which the disorder is promoted, episodic gonadotropin secretion was studied in 10 athletic women (normal ovulatory, 5; short luteal, 5) and 6 non-athletic controls. In the early follicular phase of the menstrual cycle, blood samples were obtained through an indwelling venous catheter at 15-minute intervals for 4 hours. The concentrations of luteinizing hormone (LH) and follicle-stimulating hormones (FSH) were measured by radioimmunoassay. The mean LH and FSH concentrations in the athletic groups were lower than those in the control group. LH pulse frequencies in the short luteal group were 2.8 +/- 0.2 times/four hours (mean +/- standard error) and decreased compared with that of the control group (3.7 +/- 0.2 times/four hours; p less than 0.001). The LH pulse amplitudes of all three groups were similar. Pulsatile FSH secretion was also observed in all the women. Dynamism of FSH was the same as that of LH except for low pulse amplitude in the athletic groups. These data suggest that hypothalamic-pituitary axis insufficiency, especially of hypothalamic origin may be caused by athletic activity.
在从事体育活动的女性中，经常会出现黄体功能不全、月经过少和闭经等月经紊乱情况。有人认为，此类紊乱可能与体育活动导致的下丘脑 - 垂体轴功能不全有关。为了研究这种紊乱加剧的机制，对10名从事体育活动的女性（正常排卵者5名；黄体期短者5名）和6名非体育活动对照者的促性腺激素脉冲式分泌情况进行了研究。在月经周期的卵泡早期，通过留置静脉导管每隔15分钟采集一次血样，共采集4小时。采用放射免疫分析法测定黄体生成素（LH）和卵泡刺激素（FSH）的浓度。从事体育活动组的LH和FSH平均浓度低于对照组。黄体期短组的LH脉冲频率为2.8±0.2次/4小时（平均值±标准误），与对照组（3.7±0.2次/4小时；p<0.001）相比有所降低。三组的LH脉冲幅度相似。所有女性均观察到FSH的脉冲式分泌。除从事体育活动组的脉冲幅度较低外，FSH的动态变化与LH相同。这些数据表明，体育活动可能导致下丘脑 - 垂体轴功能不全，尤其是下丘脑源性的功能不全。
