Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids.
作者信息
Marsault Eric, Benakli Kamel, Beaubien Sylvie, Saint-Louis Carl, Déziel Robert, Fraser Graeme
机构信息
Tranzyme Pharma Inc. 3001, 12e av Nord, Sherbrooke, PQ, Canada J1H5N4.
出版信息
Bioorg Med Chem Lett. 2007 Aug 1;17(15):4187-90. doi: 10.1016/j.bmcl.2007.05.043. Epub 2007 May 18.
PMID:17533127
Abstract
Novel, potent small molecule motilin receptor antagonists are described. These peptidomimetic macrocycles are composed of a tripeptide cyclized backbone-to-backbone with a nonpeptidic tether and bear new unnatural amino acids containing basic side chains.
摘要
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