Poitras Pierre, Peeters Theo L
Centre Hospitalier de l'Université de Montréal, Canada.
Curr Opin Endocrinol Diabetes Obes. 2008 Feb;15(1):54-7. doi: 10.1097/MED.0b013e3282f370af.
Motilin is a hormone produced from endocrine cells of the duodenal mucosa to help regulate motility of the digestive tract. This review discusses new findings on the potential impact of motilin in human medicine.
Motilin is a member of the peptide family that includes ghrelin whose cDNA also encodes a new candidate peptide, obestatin. Physiological interactions between these products will have to be explored. Pharmacological agents, agonists as well as antagonists, to motilin receptors are now emerging for clinical application. Motilin-receptor characterization, regarding its localization on nerves or muscles, as well as its biochemical mechanisms to sensitization for example, will be important steps in the design of future motilin agonists or antagonists.
Motilin is a fascinating hormone for the physiologist. Its interaction with the family member ghrelin and with obestatin will open new areas for basic research. Motilin-receptor agonists or antagonists could soon be part of the therapeutic arsenal of the clinician to improve digestive dysmotility.
胃动素是一种由十二指肠黏膜内分泌细胞产生的激素，有助于调节消化道的运动。本综述讨论了胃动素在人类医学中潜在影响的新发现。
胃动素是肽家族的成员，该家族包括胃饥饿素，其cDNA也编码一种新的候选肽——肥胖抑制素。必须探索这些产物之间的生理相互作用。目前正在出现用于临床应用的胃动素受体的药理学试剂，包括激动剂和拮抗剂。胃动素受体的特性，例如其在神经或肌肉上的定位以及其致敏的生化机制，将是未来设计胃动素激动剂或拮抗剂的重要步骤。
胃动素对生理学家来说是一种迷人的激素。它与家族成员胃饥饿素和肥胖抑制素的相互作用将为基础研究开辟新领域。胃动素受体激动剂或拮抗剂可能很快成为临床医生治疗消化动力障碍的治疗手段之一。
