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Synthesis and SAR of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives as non-peptidic motilin receptor antagonists.

作者信息

Johnson Sigmond G, Gunnet Joseph W, Moore John B, Miller William, Wines Pam, Rivero Ralph A, Combs Don, Demarest Keith T

机构信息

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 1000 Rt. 202, PO Box 300, Raritan, NJ 08869, USA.

出版信息

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3362-6. doi: 10.1016/j.bmcl.2006.04.017. Epub 2006 May 2.

DOI:10.1016/j.bmcl.2006.04.017
PMID:16650762
Abstract

A series of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives were synthesized as motilin receptor antagonists. Starting from known motilin antagonists, 1a and 1b, the cyclopentene scaffold was replaced and the four recognition elements optimized to arrive at a potent novel series.

摘要

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