Baum M K, Mantero-Atienza E, Shor-Posner G, Fletcher M A, Morgan R, Eisdorfer C, Sauberlich H E, Cornwell P E, Beach R S
Department of Epidemiology and Public Health, University of Miami School of Medicine, FL 33101.
J Acquir Immune Defic Syndr (1988). 1991;4(11):1122-32.
Nutritional deficiencies have been documented to affect immune function. The present study indicates that vitamin B6 deficiency is prevalent in CDC stage III HIV-1-infected subjects, despite adequate dietary vitamin B6 intake. As vitamin B6 deficiency has been previously shown to affect immune function, these relatively asymptomatic HIV-1-infected patients were examined for evidence of a relationship between vitamin B6 deficiency and immune dysregulation. Vitamin B6 status in HIV-1-infected subjects was significantly associated with functional parameters of immunity [multivariate F(3,36) = 3.70, p less than or equal to 0.02]. Additional analyses indicated that overtly deficient participants exhibited significantly decreased lymphocyte responsiveness to the mitogens phytohemagglutinin and pokeweed, and reduced natural killer cell cytotoxicity, compared to subjects with clearly adequate vitamin B6 status (chi 2 = 8.78, df = 3, p less than 0.04). Vitamin B6 status was not related to immune cell subpopulations, e.g., CD4, CD8 cell number, or level of serum immunoglobulins. The results of this study indicate that while vitamin B6 status is not a primary etiological factor in HIV-1-related immunological dysregulation, it appears to be an important cofactor of immune function.
营养缺乏已被证明会影响免疫功能。本研究表明，尽管膳食中维生素B6摄入量充足，但在疾病控制中心（CDC）III期HIV-1感染受试者中维生素B6缺乏症仍很普遍。由于先前已证明维生素B6缺乏会影响免疫功能，因此对这些相对无症状的HIV-1感染患者进行了检查，以寻找维生素B6缺乏与免疫失调之间关系的证据。HIV-1感染受试者的维生素B6状态与免疫功能参数显著相关[多变量F(3,36) = 3.70，p≤0.02]。进一步分析表明，与维生素B6状态明显充足的受试者相比，明显缺乏的参与者对丝裂原植物血凝素和商陆的淋巴细胞反应性显著降低，自然杀伤细胞细胞毒性降低（卡方= 8.78，自由度= 3，p < 0.04）。维生素B6状态与免疫细胞亚群无关，例如CD4、CD8细胞数量或血清免疫球蛋白水平。本研究结果表明，虽然维生素B6状态不是HIV-1相关免疫失调的主要病因，但它似乎是免疫功能的重要辅助因素。
