Kawai K, Meydani S N, Urassa W, Wu D, Mugusi F M, Saathoff E, Bosch R J, Villamor E, Spiegelman D, Fawzi W W
Department of Epidemiology,Harvard School of Public Health, Boston, MA,USA.
Nutritional Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging, Department of Pathology at the Sackler Graduate School of Biochemical Sciences, and Friedman School of Nutrition Science and Policy,Tufts University,Boston, MAUSA.
Epidemiol Infect. 2014 Jul;142(7):1505-9. doi: 10.1017/S0950268813002495. Epub 2013 Oct 7.
Limited studies exist regarding whether incorporating micronutrient supplements during tuberculosis (TB) treatment may improve cell-mediated immune response. We examined the effect of micronutrient supplementation on lymphocyte proliferation response to mycobacteria or T-cell mitogens in a randomized trial conducted on 423 patients with pulmonary TB. Eligible participants were randomly assigned to receive a daily dose of micronutrients (vitamins A, B-complex, C, E, and selenium) or placebo at the time of initiation of TB treatment. We found no overall effect of micronutrient supplements on lymphocyte proliferative responses to phytohaemagglutinin or purified protein derivatives in HIV-negative and HIV-positive TB patients. Of HIV-negative TB patients, the micronutrient group tended to show higher proliferative responses to concanavalin A than the placebo group, although the clinical relevance of this finding is not readily notable. The role of nutritional intervention in this vulnerable population remains an important area of future research.
关于在结核病（TB）治疗期间补充微量营养素是否可改善细胞介导的免疫反应，相关研究有限。我们在一项针对423例肺结核患者的随机试验中，研究了补充微量营养素对淋巴细胞增殖反应（针对分枝杆菌或T细胞有丝分裂原）的影响。符合条件的参与者在开始结核病治疗时被随机分配，每日服用一剂微量营养素（维生素A、复合维生素B、维生素C、维生素E和硒）或安慰剂。我们发现，在HIV阴性和HIV阳性的结核病患者中，微量营养素补充剂对淋巴细胞对植物血凝素或纯化蛋白衍生物的增殖反应没有总体影响。在HIV阴性的结核病患者中，微量营养素组对刀豆球蛋白A的增殖反应往往高于安慰剂组，尽管这一发现的临床相关性并不明显。营养干预在这一脆弱人群中的作用仍然是未来研究的一个重要领域。
