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有或没有红细胞生成的神经保护作用；有时少即是多。

Neuroprotection with or without erythropoiesis; sometimes less is more.

作者信息

Torup L

机构信息

Section of Neuropharmacology, Division of Disease Pharmacology, H Lundbeck A/S, Ottiliavej 9, 2500 Copenhagen, Denmark.

出版信息

Br J Pharmacol. 2007 Aug;151(8):1141-2. doi: 10.1038/sj.bjp.0707287. Epub 2007 May 29.

DOI:10.1038/sj.bjp.0707287
PMID:17533424
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189815/
Abstract

Erythropoietin (EPO) is a pleiotropic cytokine with a therapeutic potential that goes well beyond the treatment of anaemia. The study by Wang et al (2007b) examined the protective effects of EPO in a rat model of embolic stroke. The efficacy and haematological side effects of EPO were compared to those of a carbamylated EPO variant (CEPO). Treatment with EPO dose-dependently reduced infarct volume and improved long-term functional outcome. However, an increase in hematocrit was seen even for doses of EPO that did not offer neuroprotection. These data do not suggest the existence of a therapeutic window between effect and side effect for treatment with EPO. Treatment with CEPO was without haematological side effects.

摘要

促红细胞生成素（EPO）是一种多效性细胞因子，其治疗潜力远不止于治疗贫血。Wang等人（2007b）的研究在栓塞性中风大鼠模型中检验了EPO的保护作用。将EPO与一种氨甲酰化EPO变体（CEPO）的疗效和血液学副作用进行了比较。EPO治疗可剂量依赖性地减少梗死体积并改善长期功能结局。然而，即使是未提供神经保护作用的EPO剂量也会导致血细胞比容升高。这些数据并不表明EPO治疗在疗效和副作用之间存在治疗窗。CEPO治疗无血液学副作用。

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2
Post-ischemic treatment with erythropoietin or carbamylated erythropoietin reduces infarction and improves neurological outcome in a rat model of focal cerebral ischemia.在局灶性脑缺血大鼠模型中，用促红细胞生成素或氨甲酰化促红细胞生成素进行缺血后治疗可减少梗死面积并改善神经功能结局。
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3
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A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery.促红细胞生成素受体在神经发生和中风后恢复中的关键作用。
J Neurosci. 2006 Jan 25;26(4):1269-74. doi: 10.1523/JNEUROSCI.4480-05.2006.
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J Neurotrauma. 2005 Sep;22(9):1011-7. doi: 10.1089/neu.2005.22.1011.
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