Nettleship J E, Pugh P J, Channer K S, Jones T, Jones R D
Hormone & Vascular Biology Group, Academic Unit of Diabetes Endocrinology & Metabolism, The University of Sheffield Medical School, Sheffield, UK.
Horm Metab Res. 2007 May;39(5):366-71. doi: 10.1055/s-2007-976543.
To examine the relationship between serum levels of inflammatory cytokines and testosterone in men with stable coronary artery disease (CAD). Evidence supports a beneficial effect of testosterone upon objective measures of myocardial ischaemia in men with CAD, and in animal models of atherosclerosis. Inflammatory cytokines are involved in many stages of the atherosclerotic process, however, the effect of testosterone upon inflammatory cytokines within the cardiovascular system is largely unknown.
Serum was collected from 69 men (59+/-1 years) having >75% occlusion of 1, 2, or 3 coronary arteries. Levels of total testosterone (TT), bioavailable testosterone (BT), tumour necrosis factor-alpha (TNFalpha), interleukin (IL)-1-beta (IL-1beta), IL-6 and IL-10 were measured and analysis made between men with 1, 2, or 3 vessel CAD, and between men with hypogonadal, borderline hypogonadal and eugonadal serum levels of testosterone.
In patients with 1, 2, or 3 vessel CAD, significant stepwise increases were observed in levels of IL-1beta: 0.16+/-0.03, 0.22+/-0.06, and 0.41+/-0.08 pg/ml (p=0.035), and IL-10: 0.93+/-0.11, 1.17+/-0.14, and 2.94+/-0.65 pg/ml (p=0.008). A significant stepwise increase in levels of IL-1beta was also observed in eugonadal, borderline hypogonadal, and hypogonadal men: 0.19+/-0.05, 0.29+/-0.05, and 0.46+/-0.13 pg/ml (p=0.047).
Consequently this data implicates IL-1beta and IL-10 in the pathogenesis of CAD and suggests that testosterone may regulate IL-1beta activity in men with CAD.
研究稳定型冠状动脉疾病（CAD）男性患者血清炎症细胞因子水平与睾酮之间的关系。有证据表明，睾酮对CAD男性患者的心肌缺血客观指标以及动脉粥样硬化动物模型具有有益作用。然而，炎症细胞因子参与动脉粥样硬化过程的多个阶段，而睾酮对心血管系统内炎症细胞因子的影响在很大程度上尚不清楚。
收集69名男性（59±1岁）的血清，这些男性的1支、2支或3支冠状动脉闭塞程度>75%。测量总睾酮（TT）、生物可利用睾酮（BT）、肿瘤坏死因子-α（TNFα）、白细胞介素（IL）-1-β（IL-1β）、IL-6和IL-10的水平，并对1支、2支或3支血管CAD患者之间以及睾酮水平处于性腺功能减退、边缘性腺功能减退和性腺功能正常的男性之间进行分析。
在1支、2支或3支血管CAD患者中，观察到IL-1β水平显著逐步升高：分别为0.16±0.03、0.22±0.06和0.41±0.08 pg/ml（p=0.035），IL-10水平也显著逐步升高：分别为0.93±0.11、1.17±0.14和2.94±0.65 pg/ml（p=0.008）。在性腺功能正常、边缘性腺功能减退和性腺功能减退的男性中，也观察到IL-1β水平显著逐步升高：分别为0.19±0.05、0.29±0.05和0.46±0.13 pg/ml（p=0.047）。
因此，这些数据表明IL-1β和IL-10与CAD的发病机制有关，并提示睾酮可能调节CAD男性患者的IL-1β活性。
