Liu Kuangzheng, Chen Xinglin, Ren Xiaohan, Wu Yuqing, Ren Shancheng, Qin Chao
Medical College, Southeast University, Nanjing, China.
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Asian J Urol. 2021 Jul;8(3):303-314. doi: 10.1016/j.ajur.2020.11.004. Epub 2020 Nov 30.
Corona virus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which leads to acute respiratory infection symptoms. SARS-CoV-2 infection is not always limited to the respiratory tract, and renal infection and dysfunction have been shown to be specific risk factors for death. In addition, COVID-19 has a higher incidence, severity and mortality in men than women. This disparity is due to biological rather than comorbid or behavioral sex differences. Because the male reproductive system is unique, the function of sex hormones in COVID-19 infection may explain the differences between males and females. Understanding these factors will provide appropriate prevention measures and adequate triage strategies and guide the drug discovery process.
An electronic search was completed in PubMed, ARXIV, MEDRXIV and BIORXIV. The most relevant articles were systematically reviewed. In addition, single cell RNA sequencing analysis of tissue samples from human cell landscape was conducted.
The influence of SARS-CoV-2 on the urogenital system, the possibility of urinary tract transmission and the functions of sex hormones were discussed in this review.
Corona viruses can invade the genitourinary system, causing urological symptoms. Identifying the potential genitourinary organ impairments and protecting them from damage are necessary. Since sex hormones have potential as specific drugs, the gonadal hormones substitution therapy should be considered in both sexes in the COVID-19 pandemic.
2019冠状病毒病（COVID-19）由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起，可导致急性呼吸道感染症状。SARS-CoV-2感染并不总是局限于呼吸道，肾脏感染和功能障碍已被证明是死亡的特定危险因素。此外，COVID-19在男性中的发病率、严重程度和死亡率高于女性。这种差异是由于生物学因素而非合并症或行为方面的性别差异。由于男性生殖系统独特，性激素在COVID-19感染中的作用可能解释了男性和女性之间的差异。了解这些因素将提供适当的预防措施和充分的分诊策略，并指导药物研发过程。
在PubMed、ARXIV、MEDRXIV和BIORXIV上完成了电子检索。对最相关的文章进行了系统综述。此外，还对来自人类细胞图谱的组织样本进行了单细胞RNA测序分析。
本综述讨论了SARS-CoV-2对泌尿生殖系统的影响、尿路传播的可能性以及性激素的作用。
冠状病毒可侵入泌尿生殖系统，引起泌尿系统症状。识别潜在的泌尿生殖器官损伤并保护其免受损害是必要的。由于性激素有作为特定药物的潜力，在COVID-19大流行期间，两性均应考虑性腺激素替代疗法。
