Taylor Stephen
Department of Psychiatry, Behavioral Sciences, University of Louisville, School of Medicine, 501 E Broadway, Med Center 1, Suite 340, Louisville, KY 40202, USA.
South Med J. 2007 May;100(5):494-8. doi: 10.1097/SMJ.0b013e318038fce0.
Electroconvulsive therapy (ECT) is a safe and effective treatment for severe and persistent depression, bipolar disorder and schizophrenia. Though ECT is now over 60 years old, it remains an underutilized treatment today. History, patient selection, safety, and characteristics of the treatment stimulus, technique, and medications used in ECT are reviewed. Dosing strategies, as pertaining to seizure threshold, will be considered. Mechanisms of action, especially with regard to serotonin, norepinephrine, and dopamine receptor expression will be discussed.
电休克疗法（ECT）是治疗重度持续性抑郁症、双相情感障碍和精神分裂症的一种安全有效的方法。尽管ECT已有60多年的历史，但在如今它仍是一种未得到充分利用的治疗方法。本文回顾了ECT的历史、患者选择、安全性以及治疗刺激、技术和所用药物的特点。还将考虑与癫痫发作阈值相关的给药策略。将讨论其作用机制，特别是与5-羟色胺、去甲肾上腺素和多巴胺受体表达有关的机制。
