The Economo-Koskinas atlas revisited: cytoarchitectonics and functional context.

The monumental Atlas of Cytoarchitectonics of the Adult Human Cerebral Cortex of Economo and Koskinas represents a gigantic intellectual and technical effort, never sufficiently recognized. One reason might have been the limited number of copies produced; another, the complex (albeit logical and precise) symbol notation, which comprises a Roman capital (from the initial of the respective lobe), a calligraphic capital (the sequence of a gyrus within a lobe), and a Latin or Greek subscript (for microscopic features). Economo and Koskinas defined 107 cortical areas, as opposed to Brodmann's 44 areas for the human brain. Their cytoarchitectonic criteria confer the advantage of a more detailed parcellation scheme, despite the traditional familiarity of neuroscientists with Brodmann numbers. The system of 107 areas of Economo and Koskinas may be especially useful for modern studies on functional localization.