肛周乳腺外佩吉特病的一种治疗方法：局部使用咪喹莫特可能有助于预防或推迟手术。
A therapeutic approach to perianal extramammary Paget's disease: topical imiquimod can be useful to prevent or defer surgery.
作者信息
Vereecken Pierre, Awada Ahmad, Ghanem Ghanem, Marques da Costa Claudia, Larsimont Denis, Simoens Christian, Mendes da Costa Pierre, Hendlisz Alain
机构信息
Departments of Dermatology, CHU-Brugmann Hospital, Brussels, Belgium.
出版信息
Med Sci Monit. 2007 Jun;13(6):CS75-7.
BACKGROUND
Extramammary Paget's disease (EMPD) is a rare skin disease which can be limited to the epidermis and can sometimes also be associated with underlying carcinomas. At clinical examination, lesions are well-defined eczematous areas and have been described typically in the anogenital region. Surgery is the cornerstone treatment.
CASE REPORT
In this report the case of a 66-year-old patient presenting with a long-lasting EMPD of perianal region without deep gastrointestinal neoplasia is described. Because of the extension of the lesion, surgery should have led to abdominoperineal amputation, but the patient rejected this option. Three months of daily application of topical imiquimod was prescribed as an alternative treatment. Biopsy-confirmed complete regression could be observed thereafter, and no recurrence has been noted during a 12-month follow-up.
CONCLUSIONS
This successful treatment of a perianal-located EMPD by topical imiquimod warrants further investigations.
背景
乳房外佩吉特病（EMPD）是一种罕见的皮肤病，可局限于表皮，有时也与潜在的癌相关。临床检查时，病变为边界清晰的湿疹样区域，典型地见于肛门生殖器区域。手术是主要治疗方法。
病例报告
本报告描述了一名66岁患者，患有肛周长期EMPD，无深部胃肠道肿瘤。由于病变范围广，手术本应导致腹会阴切除术，但患者拒绝了该方案。作为替代治疗，处方了为期三个月的每日外用咪喹莫特。此后观察到活检证实完全消退，在12个月的随访中未发现复发。
结论
外用咪喹莫特成功治疗肛周EMPD值得进一步研究。
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