外用咪喹莫特治疗外阴佩吉特病：1例报告并文献复习
Treatment of vulvar Paget disease with topical imiquimod: a case report and review of the literature.
作者信息
Feldmeyer Laurence, Kerl Katrin, Kamarashev Jivko, de Viragh Pierre, French Lars E
机构信息
Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland.
出版信息
J Dermatol Case Rep. 2011 Sep 21;5(3):42-6. doi: 10.3315/jdcr.2011.1073.
BACKGROUND
Extramammary Paget's disease is a cutaneous neoplasm that presents as erythematous crusted patches and plaques reminiscent of contact dermatitis or inverse psoriasis that can be a challenge to treat in a tissue-sparing manner. The most commonly involved site for this rare disorder is the anogenital region. Surgery is considered as the gold standard therapy. In the last years, the topical use of imiquimod cream in the treatment of this condition has been reported.
MAIN OBSERVATIONS
We present a case of a 59-year-old woman with primary extramammary Paget's disease of the vulva, in which a conservative approach to therapy was desired, and who underwent complete and stable remission with imiquimod cream. We also review the previous reports of patients with extramammary Paget's disease treated with imiquimod cream.
CONCLUSIONS
Imiquimod therapy may be an alternative for primary as well as recurring extramammary Paget's disease. Treatment-associated morbidity is minimal compared with other therapies, such as surgery which may be debilitating.
背景
乳房外佩吉特病是一种皮肤肿瘤，表现为红斑性结痂斑块，类似接触性皮炎或反向银屑病，以保留组织的方式进行治疗具有挑战性。这种罕见疾病最常累及的部位是肛门生殖器区域。手术被认为是金标准治疗方法。近年来，已有报道局部使用咪喹莫特乳膏治疗这种疾病。
主要观察结果
我们报告了一例59岁女性原发性外阴乳房外佩吉特病患者，该患者希望采用保守治疗方法，使用咪喹莫特乳膏后实现了完全且稳定的缓解。我们还回顾了先前用咪喹莫特乳膏治疗乳房外佩吉特病患者的报道。
结论
咪喹莫特治疗可能是原发性及复发性乳房外佩吉特病的一种替代治疗方法。与其他治疗方法（如可能导致身体虚弱的手术）相比，治疗相关的发病率极低。
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