Photodynamic Therapy Laboratory, Department of Pathology, Wroclaw Medical University, Wroclaw, Poland.
Med Sci Monit. 2012 Feb;18(2):PI5-9. doi: 10.12659/msm.882449.
Common skin tumors like basal- and squamous-cell carcinoma present a serious problem in modern medicine. Exposure to ultraviolet solar radiation is the main cause of these lesions. Since application of Aldara and PDT separately is well documented, we decided to use both methods together. The aim of our study was to evaluate the effectiveness of local photodynamic therapy supplemented with topical application of Aldara in basal-cell carcinoma.
MATERIAL/METHODS: Thirty-four patients ages 50 to 68 years were enrolled to the trial and underwent PDT treatment. Each case of BCC was histopathologically confirmed. Ten patients were subjected to local Levulan-PDT and placebo (Eucerin as vehicle cream), and 24 patients were subjected to Levulan-PDT and imiquimod. Photodynamic diagnosis (PDD) was used to detect and visualize suspicious foci (including cancer lesions).
In the group of patients who were treated using Levulan-PDT and placebo, 6 patients (60%) were totally cured and 4 lesions (40%) significantly decreased in size. In the group of patients treated with Levulan-PDT and imiquimod, 18 lesions totally disappeared (75%), 6 lesions significantly diminished, and in 1 patient small foci of previously excised BCC developed again in scar tissue 10 month after the first control examination.
Cure was achieved without any scarring and with very good cosmetic effects. Although this is the preliminary report, the presented modification of PDT seems to be reasonable and promising in treating basal-cell carcinoma.
基底细胞癌和鳞状细胞癌等常见皮肤肿瘤是现代医学面临的严重问题。这些病变的主要原因是暴露于紫外太阳辐射。由于 Aldara 和 PDT 的单独应用已有充分的文献记载，我们决定将这两种方法联合应用。我们研究的目的是评估局部光动力疗法联合 Aldara 局部应用治疗基底细胞癌的疗效。
材料/方法：我们招募了 34 名年龄在 50 至 68 岁之间的患者进行 PDT 治疗。每个基底细胞癌病例均经组织病理学证实。10 例患者接受局部 5-氨基酮戊酸光动力疗法和安慰剂（Eucerin 作为载体乳膏）治疗，24 例患者接受 5-氨基酮戊酸光动力疗法和咪喹莫特治疗。光动力诊断（PDD）用于检测和可视化可疑病灶（包括癌症病变）。
在接受 5-氨基酮戊酸光动力疗法和安慰剂治疗的患者组中，6 例（60%）患者完全治愈，4 例（40%）病变明显缩小。在接受 5-氨基酮戊酸光动力疗法和咪喹莫特治疗的患者组中，18 例病变完全消失（75%），6 例病变明显缩小，1 例患者在首次控制检查后 10 个月，在先前切除的基底细胞癌的疤痕组织中再次出现小病灶。
治疗后无瘢痕形成，美容效果非常好。尽管这是初步报告，但这种改良的 PDT 方法似乎合理且有希望用于治疗基底细胞癌。
