Yalvac I Sagdic, Basci N E, Dulger B, Duman S
Department of Ophthalmology, Ankara Education and Research Hospital, Ankara, Turkey.
Eur J Ophthalmol. 2007 May-Jun;17(3):368-71. doi: 10.1177/112067210701700315.
To determine the intraocular penetration of topical drops of betaxolol HCl 0.25% suspension and betaxolol HCl 0.50% solution into the aqueous humor.
Fifteen patients were randomly assigned to receive topical betaxolol HCl 0.25% suspension (n=7) or topical betaxolol HCl 0.50% solution (n=8) the day before cataract surgery. Aqueous samples were collected 2 hours after the administration of the morning dose during cataract surgery. Drug concentrations were determined by high-performance liquid chromatography with fluorescence detection.
The mean aqueous humor concentration of topical betaxolol HCl 0.25% suspension was 275.1+/-168.8 micro g/mL (range 570-70 micro g/mL) and the mean aqueous humor concentration of topical betaxolol HCl 0.50% solution was 195.4+/-102.4 micro g/mL (range 334-50 micro g/mL) (p=0.281).
The mean aqueous humor concentration of betaxolol 0.25% suspension was higher than betaxolol 0.50% solution; however, the difference was not statistically significant. With twofold reduced concentration and similar anterior chamber penetration, betaxolol 0.25% suspension could be first choice for Beta 1 selective blocker therapy when considered for patients with glaucoma.
确定0.25%盐酸倍他洛尔混悬液和0.50%盐酸倍他洛尔溶液局部滴眼剂在房水中的眼内渗透率。
15例患者在白内障手术前一天被随机分配接受0.25%盐酸倍他洛尔混悬液（n = 7）或0.50%盐酸倍他洛尔溶液（n = 8）局部滴眼。在白内障手术期间，于早晨给药后2小时采集房水样本。通过高效液相色谱荧光检测法测定药物浓度。
0.25%盐酸倍他洛尔混悬液的房水平均浓度为275.1±168.8μg/mL（范围570 - 70μg/mL），0.50%盐酸倍他洛尔溶液的房水平均浓度为195.4±102.4μg/mL（范围334 - 50μg/mL）（p = 0.281）。
0.25%倍他洛尔混悬液的房水平均浓度高于0.50%倍他洛尔溶液；然而，差异无统计学意义。0.25%倍他洛尔混悬液浓度降低一半但前房渗透率相似，对于青光眼患者，在考虑β1选择性阻滞剂治疗时可能是首选。
