Cagini Carlo, Cometa Francesco, Torroni Giovanni, Pellegrino Adriana, Pellegrino Roberto, Cavallini Gian Maria
a Department of Surgical and Biomedical Sciences , University of Perugia , Perugia , Italy.
b Department of Chemistry , University of Perugia , Perugia , Italy.
Curr Eye Res. 2016 Jul;41(7):897-9. doi: 10.3109/02713683.2015.1083589. Epub 2015 Nov 18.
To study the amount of steroids that is found in the aqueous humor after topical administration of dexamethasone solution eye-drops and dexamethasone suspension eye-drops.
One hundred seventeen consecutive patients of both genders 18 years or older, candidates for cataract surgery were randomly assigned to one of three groups. Fifty-one patients (group A) received a single instillation of a suspension containing tobramicin 0.3% mg/ml + dexamethasone 0.1% mg/ml; 56 patients (group B) received a single instillation of a solution containing tobramicin 0.3% mg/ml + dexamethasone 0.1% mg/ml; 10 patients (group C), control group, did not receive any drops. Samples were taken immediately before surgery from the anterior chamber and dexamethasone levels were measured using gas chromatography/mass spectrometry.
The mean dexamethasone concentrations were 0.56 μM (min 0.00, max 3.25) in group A and 0.15 μM (min 0.00, max 2.93) in group B. Dexamethasone was not detected in samples from group C.
Dexamethasone suspension gives concentrations of steroids in the aqueous humor approximately three times higher than with dexamethasone solution drops.
研究局部应用地塞米松溶液滴眼液和地塞米松混悬液滴眼液后房水中的类固醇含量。
117例18岁及以上拟行白内障手术的连续患者，男女不限，随机分为三组。51例患者（A组）单次滴注含0.3%毫克/毫升妥布霉素+0.1%毫克/毫升地塞米松的混悬液；56例患者（B组）单次滴注含0.3%毫克/毫升妥布霉素+0.1%毫克/毫升地塞米松的溶液；10例患者（C组）为对照组，未滴注任何滴眼液。术前立即从前房采集样本，采用气相色谱/质谱法测量地塞米松水平。
A组地塞米松平均浓度为0.56μM（最小值0.00，最大值3.25），B组为0.15μM（最小值0.00，最大值2.93）。C组样本中未检测到地塞米松。
地塞米松混悬液使房水中类固醇浓度比地塞米松溶液滴眼液高出约三倍。
