Katsuragi S, Miyakawa T, Ouchi K, Kuramoto R
Department of Neuropsychiatry, Kumamoto University Medical School, Japan.
Jpn J Psychiatry Neurol. 1991 Mar;45(1):91-4. doi: 10.1111/j.1440-1819.1991.tb00511.x.
Neurofibrillary tangles (NFT) in the brains of patients with Alzheimer's disease were examined by means of tilt-stage electron microscopy. Observing a longitudinal direction, constricted parts of the NFT did not move in an axial direction. In a transverse section, a fibril of the NFT consisted of globular subunits having a hollow structure in the center and did not appear as paired filaments. From these findings, it was considered that a fibril of NFT consists of twisted protofilaments made up of globular subunits and does not consist of paired helical filaments.
通过倾斜台电子显微镜对阿尔茨海默病患者大脑中的神经原纤维缠结（NFT）进行了检查。观察纵向时，NFT的收缩部分在轴向上不移动。在横切面上，NFT的纤维由中心具有中空结构的球状亚基组成，并非成对的细丝状。从这些发现来看，认为NFT的纤维由由球状亚基组成的扭曲原纤维构成，而非由成对螺旋丝构成。
